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  • 651.
    Wikby, Anders
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Maxson, P
    Olsson, J
    Johansson, B
    Ferguson, F G
    Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study.1998Ingår i: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 102, nr 2-3, s. 187-198Artikel i tidskrift (Refereegranskat)
  • 652.
    Wikby, Anders
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Månsson, Ingrid A.
    Johansson, Boo
    Strindhall, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Nilsson, Sven E.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.2008Ingår i: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 9, nr 5, s. 299-308Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.

  • 653.
    Wikby, Anders
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Nilsson, Bengt-Olof
    Forsey, Rosalyn
    Thompson, Julie
    Strindhall, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Löfgren, Sture
    Ernerudh, Jan
    Pawelec, Graham
    Ferguson, Frederick
    Johansson, Boo
    The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning.2006Ingår i: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 127, nr 8, s. 695-704Artikel i tidskrift (Refereegranskat)
  • 654.
    Wikby, Anders
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Stenström, Ulf
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för beteendevetenskap och socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Andersson, P O
    Hörnquist, J
    Metabolic control, quality of life, and negative life events: a longitudinal study of well-controlled and poorly regulated patients with type 1 diabetes after changeover to insulin pen treatment.1998Ingår i: The diabetes educator, ISSN 0145-7217, E-ISSN 1554-6063, Vol. 24, nr 1, s. 61-66Artikel i tidskrift (Refereegranskat)
  • 655.
    Wikby, Anders
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Stenström, Ulf
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för beteendevetenskap och socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Hörnquist, J O
    Andersson, P O
    Coping behaviour and degree of discrepancy between retrospective and prospective self-ratings of change in quality of life in type 1 diabetes mellitus1993Ingår i: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 10, nr 9, s. 851-854Artikel i tidskrift (Refereegranskat)
  • 656.
    Wilsson, Åsa
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    Lind, Sara
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Öhman, Lena
    Division of Medical Microbiology, Linköping University, Linköping, Sweden; and Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Nilsdotter-Augustinsson, Åsa
    Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Lundqvist-Setterud, Helen
    Division of Medical Microbiology, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-α and interleukin-62008Ingår i: FEMS Immunology and Medical Microbiology, ISSN 0928-8244, E-ISSN 1574-695X, Vol. 53, nr 1, s. 126-135Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Staphylococcus epidermidis infections are usually nosocomial and involve colonization of biomaterials. The immune defense system cannot efficiently control the bacteria during these infections, which often results in protracted chronic inflammation, in which a key event is disturbed removal of neutrophils by tissue macrophages. While ingesting uninfected apoptotic neutrophils, macrophages release anti-inflammatory cytokines that lead to resolution of inflammation. In clinical studies, we have previously found elevated levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in synovial fluid from prostheses infected with coagulase negative staphylococci. We show that macrophages phagocytosing apoptotic neutrophils containing S. epidermidis released TNF-alpha and interleukin-6, whereas macrophages phagocytosing spontaneously apoptotic neutrophils did not. This difference was not due to dissimilar phagocytic capacities, because macrophages ingested both types of neutrophils to the same extent. The activation was induced mainly by the apoptotic neutrophils themselves, not by the few remaining extracellular bacteria. Macrophages were not activated by apoptotic neutrophils that contained paraformaldehyde-killed S. epidermidis. Proinflammatory reactions induced by clearance of apoptotic neutrophils containing S. epidermidis might represent an important mechanism to combat the infective agent. This activation of macrophages may contribute to the development of chronic inflammation instead of inflammation resolution.

  • 657.
    Wohlfahrt, J. C.
    et al.
    Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
    Evensen, B. J.
    Private Practice, Tønsberg, Norway.
    Zeza, B.
    Department of Dental and Maxillofacial Sciences, Section of Periodontology, Sapienza, University of Rome, Rome, Italy.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Pilloni, A.
    Department of Dental and Maxillofacial Sciences, Section of Periodontology, Sapienza, University of Rome, Rome, Italy.
    Roos-Jansåker, A. M.
    Department of Periodontology, Public Dental Health Service, Kristianstad, Sweden.
    Di Tanna, G. L.
    Center for Primary Care and Public Health, Queen Mary University of London, London, UK.
    Aass, A. M.
    Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
    Klepp, M.
    Private Practice, Stavanger, Norway.
    Koldsland, O. C.
    Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
    A novel non-surgical method for mild peri-implantitis- a multicenter consecutive case series2017Ingår i: International Journal of Implant Dentistry, ISSN 2198-4034, Vol. 3, nr 1Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM:

    The aim of the present study was to evaluate the effect on peri-implant mucosal inflammation from the use of a novel instrument made of chitosan in the non-surgical treatment of mild peri-implantitis across several clinical centers.

    MATERIALS AND METHODS:

    In this 6-month multicenter prospective consecutive case series performed in six different periodontal specialist clinics, 63 implants in 63 patients were finally included. The subjects had mild peri-implantitis defined as radiographic bone loss of 1-2 mm, pocket probing depth (PPD) ≥4 mm and a positive bleeding on probing (mBoP) score. The patients were clinically examined at baseline and after 2, 4, 12 and 24 weeks, and radiographs were taken at baseline and at 3 and 6 months. Treatment of the implants with the chitosan brush seated in an oscillating dental drill piece was performed at baseline and at 3 months. Reductions in the clinical parameters (PPD and mBoP) were compared between baseline and the later examination time points.

    RESULTS:

    Significant reductions in both PPD and mBoP were observed at all time points compared with the baseline clinical measurements (p < 0.001). The mean PPD and mBoP at baseline were 5.15 mm (4.97; 5.32) and 1.86 (1.78; 1.93), respectively, whereas the mean PPD and mBoP at 6 months were 4.0 mm (3.91; 4.19) and 0.64 (0.54; 0.75), respectively. Stable reductions in PPD and mBoP were evident up to 6 months after the initial treatment and 3 months after the second treatment. All 63 implants were reported to have stable radiographic levels of osseous support.

    CONCLUSIONS:

    This case series demonstrated that an oscillating chitosan brush is safe to use and seems to have merits in the non-surgical treatment of dental implants with mild peri-implantitis. To measure the effectiveness of the method, a multicenter randomized clinical trial needs to be undertaken.

  • 658. Wägsäter, Dick
    et al.
    Löfgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of interleukin-17 in human colorectal cancer2006Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 26, nr 6B, s. 4213-4216Artikel i tidskrift (Refereegranskat)
  • 659. Wågsater, Dick
    et al.
    Mumtaz, Melad
    Lofgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter -420C>G genotype.2008Ingår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, nr 10, s. 1008-1014Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.

  • 660. Wågsäter, D
    et al.
    Sirsjö, A
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)2003Ingår i: Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, E-ISSN 1756-9966, Vol. 22, nr 3, s. 471-475Artikel i tidskrift (Övrigt vetenskapligt)
  • 661. Wågsäter, Dick
    et al.
    Dienus, Olaf
    Löfgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Quantification of the chemokines CCL17 and CCL22 in human colorectal adenocarcinomas2008Ingår i: Molecular Medicine Reports, ISSN 1791-2997, Vol. 1, nr 2, s. 211-217Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Chemokines are believed to play a crucial role in local immunoresponse by regulating leukocyte movement in various tissues, including the intestinal mucosa. It has been suggested that they are key players in cancer biology, and several studies have identified leukocyte infiltration as a hallmark of most cancers. The chemokines CCL17 and CCL22 attract CCR4-bearing cells, which are especially polarised to Th2-type cells and regulatory T cells (Treg). Recent studies have revealed the participation of the CCL17 and CCL22 proteins in diseases such as atopic dermatitis and lymphoma. The purpose of this study was to assess the role of CCL17 and CCL22 protein expression in colorectal cancer (CRC) and to ascertain whether an association exists between promoter -431C>T CCL17 and -961G>A CCL22 gene polymorphisms in CRC versus non-CRC subjects. Using the ELISA assay, we noted a significantly higher expression of CCL22 in tumour tissue with a 2.3-fold up-regulation (tumour vs. paired normal tissue, n=78) but no significant difference in CCL17 protein expression. Immunohistochemistry revealed protein expression of CCL22 and CCL17 in the epithelial compartment of cancer tissue, in epithelial cells at the resection border that reflects normal tissue, and in some stromal cells such as lymphocytes, macrophages, and fibroblasts. Using a TaqMan system we screened for -431C>T CCL17 and -961G>A CCL22 gene variants in 245 CRC patients and 256 controls, but could not find any significant difference in genotype distribution or in allelic frequencies between the two groups. The genotype and allelic distributions of CRC patients were not related to tissue levels of CCL17 and CCL22 protein, and none of the variables were associated with plasma levels or clinical characteristics. To ascertain whether the tissue expression of CCL17 and CCL22 exerts an influence oil the pathogenesis of CRC, a forthcoming study oil the 5-year survival rate of CRC patients will be conducted.

  • 662. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of chemokine receptor CXCR6 in human colorectal adenocarcinomas.2004Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 24, nr 6, s. 3711-3714Artikel i tidskrift (Refereegranskat)
  • 663. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Hugander, Anders
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Sirsjö, Allan
    Ghaderi, Mehran
    Analysis of MICA gene transcripts in human rectal cancers2003Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 23, nr 3B, s. 2525-2529Artikel i tidskrift (Övrigt vetenskapligt)
  • 664. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Sirsjö, Allan
    Induction of ATP-binding cassette A1 by all-trans retinoic acid: possible role of liver X receptor-alpha.2003Ingår i: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 11, nr 4, s. 419-423Artikel i tidskrift (Övrigt vetenskapligt)
  • 665. Wågsäter, Dick
    et al.
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of CXCL16 in human rectal cancer.2004Ingår i: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 14, nr 1, s. 65-69Artikel i tidskrift (Övrigt vetenskapligt)
  • 666. Wågsäter, Dick
    et al.
    Jatta, Ken
    Ocaya, Pauline
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Sirsjo, Allan
    Expression of IL-1beta, IL-1 receptor type I and IL-1 receptor antagonist in human aortic smooth muscle cells: effects of all-trans-retinoic acid.2006Ingår i: Journal of Vascular Research, ISSN 1018-1172, E-ISSN 1423-0135, Vol. 43, nr 4, s. 377-382Artikel i tidskrift (Övrigt vetenskapligt)
  • 667. Wågsäter, Dick
    et al.
    Löfgren, Sture
    Hugander, Anders
    Dienus, Olaf
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine eotaxin-1 in colorectal cancer patients2007Ingår i: World Journal of Surgical Oncology, ISSN 1477-7819, E-ISSN 1477-7819, Vol. 5, s. 84-Artikel i tidskrift (Refereegranskat)
  • 668.
    Wågsäter, Dick
    et al.
    Karolinska Institute.
    Löfgren, Sture
    Ryhov County Hospital.
    Zar, Niklas
    Ryhov County Hospital.
    Hugander, Anders
    Ryhov County Hospital.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Pigment epithelium-derived factor expression in colorectal cancer patients2010Ingår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 28, nr 8, s. 872-877Artikel i tidskrift (Refereegranskat)
  • 669.
    Zakrisson Mortensson, Elin
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    Öhlen, Malin
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    Samband mellan tandvårdsrädsla och temperament- vilken betydelse har kön och utländsk bakgrund?: En tvärsnittsstudie på ungdomar i nionde klass i Jönköpings kommun2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Sammanfattning

     

    Bakgrund: Tandvårdsrädsla är ett vanligt förekommande problem i tandvården vilket kan bidra till en sämre oral hälsa. Tidigare forskning visar vissa samband mellan tandvårdsrädsla och olika temperament men de mest signifikanta resultaten varierar. Syfte: Syftet med studien var att undersöka samband mellan tandvårdsrädsla och temperament hos ungdomar i nionde klass. Metod: Studien är en tvärsnittsstudie baserad på ett stratifierat urval av ungdomar i nionde klass. Två validerade enkäter innehållande självrapporterade frågor om tandvårdsrädsla och temperament delades ut till ungdomarna i klassrummen och samlades in vid samma tillfälle. Resultat: Totalt 111 deltog, 3 % av ungdomarna konstaterades vara tandvårdsrädda. Signifikanta samband sågs mellan blyghet och DFS-poäng. Kvinnorna hade signifikant högre medelvärde av DFS-poäng och emotionalitet jämfört med männen. Männen hade signifikant högre medelvärde i aktivitet. Inga signifikanta samband fanns mellan tandvårdsrädsla och utländsk- eller svensk bakgrund. Ungdomarna med svensk bakgrund hade högre medelvärde i temperamentet sällskaplighet jämfört med ungdomarna med utländsk bakgrund. Slutsats: Prevalensen av konstaterad tandvårdsrädsla var 3 % hos ungdomarna. Kvinnorna hade högre grad av DFS-poäng och emotionalitet. Männen rapporterade högre grad av aktivitet. Ungdomar med utländsk bakgrund hade en lägre grad av sällskaplighet. Ett signifikant samband fanns mellan DFS-poäng och temperamentet blyghet.

  • 670.
    Zasciurinskiene, Egle
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Department of Orthodontics, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lund, H.
    Department of Oral and Maxillofacial Radiology, Sahlgrenska Academy, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.
    Lindsten, Rune
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Centrum för oral hälsa. Departments of Orthodontics, Institute for Postgraduate Dental Education, Sweden.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Centrum för oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Periodontology, Institute for Postgraduate Dental Education, Sweden.
    Bjerklin, K.
    Departments of Orthodontics, Institute for Postgraduate Dental Education, Sweden.
    Outcome of orthodontic treatment in subjects with periodontal disease. Part III: a CBCT study of external apical root resorption2019Ingår i: European Journal of Orthodontics, ISSN 0141-5387, E-ISSN 1460-2210, Vol. 41, nr 6, s. 575-582Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND:

    No evidence is present on the risk for external apical root resorption (EARR) during orthodontic treatment (OT) of adult patients with periodontal disease.

    AIM:

    To examine EARR after OT in subjects with periodontal disease and to analyse how intrusion and change in inclination of the most proclined maxillary incisors influence EARR.

    METHODS:

    The study included 50 patients with periodontal disease. Sub-gingival debridement by ultrasonic instrumentation supplemented with hand instruments was performed by experienced dental hygienist after baseline examination for all patients. For the control group, final periodontal treatment (PT) was performed before orthodontic tooth movement. For the test group patients, final PT was performed after levelling and alignment phases were finished, before the active space closure with elastic chain and/or inter-arch elastic traction for sagittal correction was started. OT was performed with a straight-wire appliance. Micro-implants or implants were used for posterior anchorage. Cone beam computed tomography examinations were performed before and after OT. EARR of all single-rooted teeth were measured. EARR of the most proclined maxillary incisor was related to intrusion and change in inclination angle.

    RESULTS:

    EARR after OT was observed in median 80.7 per cent (interquartile range 22.02) of single-rooted teeth [mean 1.2 (standard deviation 0.44) mm]. In 82.3 per cent of teeth, EARR was 2 mm or less. Severe EARR was found in 8 per cent of patients and five maxillary incisors (less than 1 per cent of all teeth). The amount of intrusion and change in inclination angle of the most proclined maxillary central incisor influenced the extent of EARR. Mean EARR was significantly higher when OT lasted more than 18 months (P = 0.02).

    CONCLUSIONS:

    OT in conjunction with PT in periodontal patients resulted in EARR in 81 per cent of all single-rooted teeth. Intrusion and change in inclination angle of the most proclined maxillary central incisor influenced the extent of EARR, as did longer OT. 

  • 671.
    Zasciurinskiene, Egle
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Department of Orthodontics, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lund, H.
    Department of Oral and Maxillofacial Radiology, Sahlgrenska Academy, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.
    Lindsten, Rune
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Centrum för oral hälsa. Departments of Orthodontics, Institute for Postgraduate Dental Education, Sweden.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Centrum för oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Periodontology, Institute for Postgraduate Dental Education, Sweden.
    Bjerklin, K.
    Departments of Orthodontics, Institute for Postgraduate Dental Education, Sweden.
    Outcome of periodontal-orthodontic treatment in subjects with periodontal disease. Part II: a CBCT study of alveolar bone level changes2019Ingår i: European Journal of Orthodontics, ISSN 0141-5387, E-ISSN 1460-2210, Vol. 41, nr 6, s. 565-574Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM:

    To examine alveolar bone level (ABL) changes before (T1) and after (T2) orthodontic treatment (OT) in subjects with periodontal disease.

    METHODS:

    The study included 50 subjects with periodontal disease. All patients received subgingival debridement following baseline examination. Control group patients received final periodontal treatment before the start of OT. For the test group patients final periodontal treatment was performed simultaneous to OT. OT was performed with a straight-wire appliance. Micro-implants or temporary crowns on implants were used for posterior anchorage when needed. ABL measurements of 3821 tooth surfaces were performed on cone beam computed tomography images.

    RESULTS:

    No difference was observed between mean ABL at T1 and T2. ABL remained unchanged on 69 per cent of surfaces. A mean of 15.6 (SD 7.4) per cent of surfaces experienced ABL gain, and a mean of 15.1 (SD 7.5) per cent was found with ABL loss. Small significant median ABL difference was observed on mesial and distal surfaces (P < 0.001). A significant difference was found between median ABL changes on mesial/distal in comparison to buccal/lingual surfaces (P < 0.01). Significantly more buccal (17.9 %) and lingual (18.5 %) surfaces experienced ABL loss when compared with mesial (11.3 %) and distal (12.0 %) surfaces (P < 0.001). Significant difference was found in the median ABL change of intruded (0.5 (IQR 0.94) mm) and non-intruded (-0.4 (IQR 1.07) mm) maxillary incisors (P = 0.04). Significant median ABL gain was found on the lingual surface of maxillary incisors, which were retroclined more than 8.6 degree and intruded more than 1.6 mm.

    CONCLUSIONS:

    ABL changes after periodontal-orthodontic treatment in patients with periodontal disease were small. ABL gain was more observed on mesial and distal surfaces and ABL loss on buccal and lingual surfaces. Larger orthodontic movements of maxillary incisors influenced ABL gain. 

  • 672.
    Zasčiurinskienė, Eglė
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Department of Orthodontics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Basevičienė, Nomeda
    Department of Dental and Oral Pathology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lindsten, Rune
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Slotte, Christer
    Department of Periodontology, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Bjerklin, Krister
    Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Orthodontic treatment simultaneous to or after periodontal cause-related treatment in periodontitis susceptible patients. Part I: Clinical outcome. A randomized clinical trial2018Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 45, nr 2, s. 213-224Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aim: To compare two treatment strategies regarding the effect of orthodontic treatment on periodontal status in patients with plaque-induced periodontitis.

    Subjects and Methods: This was a randomized clinical trial. Fifty periodontal patients were randomly assigned to the test or control groups according to periodontal treatment timing. All patients received supra- and subgingival debridement following baseline examination. Control group patients received cause-related periodontal treatment before the start of orthodontic treatment and which was performed simultaneous to orthodontic treatment for the test group patients.

    Results: No difference between the test and control groups was found regarding change of clinical attachment level (CAL) after periodontal–orthodontic treatment. Fewer sites with initial pocket depth (PD) of 4–6 mm healed after periodontal–orthodontic treatment in the test group (20.5%, IQR = 11.9%) in comparison with controls (30.4%, IQR = 27.1%) (p =.03). Anterior teeth [OR 2.5] and teeth in male patients [OR 1.6] had a greater chance for PD improvement ≥2 mm. Total periodontal–orthodontic treatment duration was significantly longer for the control group (p <.01).

    Conclusions: Both groups showed a gain of CAL and a reduction in sites with PD ≥ 4 mm. Orthodontic treatment, simultaneously to the periodontal treatment, could be used in the routine treatment of patients with plaque-induced periodontitis.

  • 673.
    Zasčiurinskienė, Eglė
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Department of Orthodontics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lund, Henrik
    Department of Oral and Maxillofacial Radiology, Sahlgrenska Academy, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.
    Lindsten, Rune
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Periodontology, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Bjerklin, Krister
    Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Outcome of periodontal-orthodontic treatment in periodontitis susceptible patients. Part II: A CBCT study of external apical root resorptionManuskript (preprint) (Övrigt vetenskapligt)
  • 674.
    Zasčiurinskienė, Eglė
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Department of Orthodontics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lund, Henrik
    Department of Oral and Maxillofacial Radiology, Sahlgrenska Academy, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.
    Lindsten, Rune
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Jansson, Henrik
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Oral hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Periodontology, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Bjerklin, Krister
    Department of Orthodontics, Institute for Postgraduate Dental Education, Jönköping, Sweden.
    Outcome of periodontal-orthodontic treatment in periodontitis susceptible patients. Part III: A CBCT study of alveolar bone changesManuskript (preprint) (Övrigt vetenskapligt)
  • 675. Zulqarnain, B J
    et al.
    Furuya, R
    Hedegård, B
    Magnusson, Tomas
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    The silent period in the masseter and the anterior temporalis muscles in adult patients with mild or moderate mandibular dysfunction symptoms.1989Ingår i: Journal of Oral Rehabilitation, ISSN 0305-182X, E-ISSN 1365-2842, Vol. 16, nr 2, s. 127-137Artikel i tidskrift (Refereegranskat)
  • 676.
    Åkerman, Anna
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    Sayfawi, Refel
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin.
    Etablering av MALDI-TOF MS och webbaserad referensdatabas för identifiering av dermatofyter och mögelsvamp2018Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Syftet med studien var att etablera Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry(MALDI-TOF MS) och onlinedatabasen Mass Spectrometry identification platform(MSI) som metod för identifiering av dermatofyter och mögelsvamp. Svamparna inkuberades 3 eller 6 dagar aerobt i 30°C på Sabouraud dextros agar. Två olika extraktionsmetoder användes innan analys med MALDI-TOF MS. Spektra analyserades med Flexcontrol version 3.4 och resulterade i scorevärde. De spektra som framkom skickades även till MSI för ytterligare analys där resultat erhölls som sannolikhet i procent. Av de ursprungliga 23 st prov identifierades totalt 22st(95,6%) efter 3 eller 6 dagars inkubation och med extraktionsmetod 1 eller 2. MSI databasen var mer omfattande än den interna databasen, men använde sig inte av de aktuella namnen. Behovet av artidentifiering kan ifrågasättas, då många dermatofyter och mögel inom samma släkte behandlas på samma sätt. Artbestämning för immunsupprimerade patienter kan däremot vara viktigt. Studien var lyckad och metoderna kommer tillämpas inom en snar framtid på Klinisk Mikrobiologi i Halmstad.

  • 677. Åkesson, K
    et al.
    Tompa, Andrea
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Rydén, A
    Faresjö, Maria
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Low expression of CD39+/CD45RA+ on regulatory T cells (Treg) cells in type 1 diabetic children in contrast to high expression of CD101+/CD129+ on Treg cells in children with coeliac disease2014Ingår i: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 180, s. 70-82Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Type 1 diabetes (T1D) and coeliac disease are both characterized by an autoimmune feature. As T1D and coeliac disease share the same risk genes, patients risk subsequently developing the other disease. This study aimed to investigate the expression of T helper (Th), T cytotoxic (Tc) and regulatory T cells (Treg) in T1D and/or coeliac disease children in comparison to healthy children. Subgroups of T cells (Th:CD4+ or Tc:CD8+); naive (CD27+CD28+CD45RA+CCR7+), central memory (CD27+CD28+CD45RA-CCR7+), effector memory (early differentiated; CD27+CD28+CD45RA-CCR7- and late differentiated; CD27-CD28-CD45RA-CCR7-), terminally differentiated effector cells (TEMRA; CD27-CD28-CD45RA+CCR7-) and Treg (CD4+CD25+FOXP3+CD127-) cells, and their expression of CD39, CD45RA, CD101 and CD129, were studied by flow cytometry in T1D and/or coeliac disease children or without any of these diseases (reference group). Children diagnosed with both T1D and coeliac disease showed a higher percentage of TEMRA CD4+ cells (P<0·05), but lower percentages of both early and late effector memory CD8+ cells (P<0·05) compared to references. Children with exclusively T1D had lower median fluorescence intensity (MFI) of forkhead box protein 3 (FoxP3) (P<0·05) and also a lower percentage of CD39+ and CD45RA+ within the Treg population (CD4+CD25+FOXP3+CD127-) (P<0·05). Children with exclusively coeliac disease had a higher MFI of CD101 (P<0·01), as well as a higher percentage of CD129+ (P<0·05), in the CD4+CD25hi lymphocyte population, compared to references. In conclusion, children with combined T1D and coeliac disease have a higher percentage of differentiated CD4+ cells compared to CD8+ cells. T1D children show signs of low CD39+/CD45RA+ Treg cells that may indicate loss of suppressive function. Conversely, children with coeliac disease show signs of CD101+/CD129+ Treg cells that may indicate suppressor activity.

  • 678.
    Ögren, Jessica
    et al.
    Division of Medical Diagnostics, Clinical Microbiology Laboratory, County Hospital Ryhov, Region Jönköping County, Sweden.
    Van Nguyen, Song
    Department of Medical Laboratory, Da Nang University of Medical Technology and Pharmacy, Da Nang, Vietnam.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Matussek, Andreas
    Division of Medical Diagnostics, Clinical Microbiology Laboratory, County Hospital Ryhov, Region Jönköping County, Sweden.
    Prevalence of Dientamoeba fragilis, Giardia duodenalis, Entamoeba histolytica/dispar, and Cryptosporidium spp inDa Nang, Vietnam, detected by a multiplex real-time PCR2016Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 124, nr 6, s. 529-533Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We surveyed the prevalence of Dientamoeba fragilis, Giardia duodenalis, Entamoeba histolytica, Entamoeba dispar, and Cryptosporidium spp in individuals with and without gastrointestinal (GI) symptoms residing in and around Da Nang city, Vietnam. Fecal samples were collected from children (n = 100) and adults (n = 80) with GI symptoms and from healthy individuals (n = 88) reporting no GI symptoms. Parasite detection was performed by multiplex real-time PCR. Overall, except for G. duodenalis, we found a low prevalence (<5%) of D. fragilis and E. dispar and no detection of E. histolytica and C. spp in all participants with GI symptoms. Specifically for D. fragilis this contrasts with findings in European populations of children with GI symptoms showing prevalence up to 73%. Moreover, our results indicate that the prevalence of G. duodenalis is higher in patients with GI symptoms compared to asymptomatic individuals and this difference is most obvious in young patients.

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