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  • 51.
    Sidenvall, Birgitta
    Jönköping University, School of Health Science, HHJ, Dep. of Nursing Science. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Ätandet under livets olika skeden2003In: Svårigheter att äta / [ed] Albert Westergren, Lund: Studentlitteratur , 2003Chapter in book (Other academic)
  • 52.
    Sindi, S.
    et al.
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Ngandu, T.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
    Hovatta, I.
    Department of Biosciences, University of Helsinki, Helsinki, Finland.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Antikainen, R.
    Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
    Hänninen, T.
    Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland.
    Levälahti, E.
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Laatikainend, T.
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Lindström, J.
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Paajanen, T.
    Institute of Occupational Health, Helsinki, Finland.
    Peltonen, M.
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Khalsa, D. S.
    Department of General Internal Medicine, Geriatrics and Integrative Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    Wolozin, B.
    Departments of Pharmacology and Neurology, Boston University School of Medicine, Boston, MA, USA.
    Strandberg, T.
    Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
    Tuomilehto, J.
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Soininen, H.
    Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland.
    Kivipelto, M.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
    Solomon, A.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
    Baseline telomere length and effects of a multidomain lifestyle intervention on cognition: The FINGER randomized controlled trial2017In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 59, no 4, p. 1459-1470Article in journal (Refereed)
    Abstract [en]

    Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: Memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals.

  • 53.
    Sindi, Shireen
    et al.
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Johansson, Lena
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden.
    Skoog, Johan
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden.
    Sjöberg, Linnea
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Wang, Hui-Xin
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Johansson, Boo
    Department of Psychology, Center for Health and Ageing AGECAP, University of Gothenburg, Sweden.
    Fratiglioni, Laura
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Soininen, Hilkka
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
    Solomon, Alina
    Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Skoog, Ingmar
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden..
    Kivipelto, Miia
    Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, United Kingdom.
    Sleep disturbances and dementia risk: A multicenter study2018In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 10, p. 1235-1242Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk.

    METHODS: Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3-10 years follow-up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407).

    RESULTS: Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87-8.48).

    DISCUSSION: Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk.

  • 54.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Omsorgsmönster bland äldre kvinnor och män i Norden1991In: Gamle kvinner i Norden: deres liv i tekst og tall / [ed] Anne Helset, Oslo: Norsk gerontologisk institutt , 1991Chapter in book (Other academic)
  • 55. Torres, Sandra
    Invandrarskap och hög ålder: att åldras i Sverige som invandrare2011In: Äldre och åldrande: Grundbok i gerontologi / [ed] Marie Ernsth Bravell, Stockholm: Gothia Förlag AB , 2011, 1, p. 89-108Chapter in book (Other academic)
  • 56.
    Wahlin, Åke
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Är vi beredda att leva i ett ålderslöst samhälle?2014In: Tidningen Ä, ISSN 2001-1164, no 2, p. 38-38Article in journal (Other (popular science, discussion, etc.))
12 51 - 56 of 56
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