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  • 1051. Winterling, Jeanette
    et al.
    Wasteson, Elisabet
    Sidenvall, Birgitta
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för omvårdnad. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Sidenvall, Erik
    Glimelius, Bengt
    Sjödén, Per-Olow
    Nordin, Karin
    Relevance of philosophy of life and optimism for psychological distress among individuals in a stage where death is approaching.2006Ingår i: Supportive Care in Cancer, ISSN 0941-4355, E-ISSN 1433-7339, Vol. 14, nr 4, s. 310-319Artikel i tidskrift (Refereegranskat)
  • 1052. Wray, L
    et al.
    Beverly, E
    Gold, C
    Berg, Stig
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. HHJ. Åldrande - livsvillkor och hälsa.
    Malmberg, Bo
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. HHJ. Åldrande - livsvillkor och hälsa.
    Pedersen, N
    McClearn, G E
    Socioeconomic status, health behaviors and comorbidity2004Ingår i: 17. Nordiska Kongressen i Gerontologi, Stockholm, 2004Konferensbidrag (Refereegranskat)
  • 1053. Wretstrand, Anders
    et al.
    Bylund, Per-Olof
    Petzäll, Jan
    Falkmer, Torbjörn
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för rehabilitering. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Injuries in special transport services: Situations and risk levels involving wheelchair users2010Ingår i: Medical Engineering and Physics, ISSN 1350-4533, E-ISSN 1873-4030, Vol. 32, nr 3, s. 248-253Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Previous research has shown that wheelchair-seated passengers using special transportation services (STS) have been injured without being involved in a vehicle crash. In order to estimate incident rate andsocietal costs for these vehicle-related injuries, the focus needs to be adjusted towards a traveler/incidentoriented perspective. The aim of the project was to utilize such a perspective, related to travelers using STS in Sweden. In order to address the chosen perspective, a mixed method approach was used, involving quantitative as well as qualitative research techniques applied on four different sets of data: one hospital-based record,two sets of STS incident report databases, and interviews with wheelchair-seated STS passengers. The results showed that the injury incidence rate in STS is considerable, i.e. 10 per 100,000 trips. However, this high incidence rate is not due to road traffic collisions, but to non-collision injury incidents involving many elderly and frail passengers, who easily sustain traumas ranging from minor to moderate. The costs were estimated to be 23 million USD per annum or 14 USD per trip. Results suggest that future injury prevention measures should focus on safety in boarding and alighting procedures, as well as thecontinuing development of WTORS.

     

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  • 1054. Wretstrand, Anders
    et al.
    Svensson, Helena
    Fristedt, Sofi
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Falkmer, Torbjörn
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för rehabilitering.
    Older people and local public transit: Mobility effects of accessibility improvements in Sweden2009Ingår i: Journal of Transport and Land Use, ISSN 1938-7849, Vol. 2, nr 2, s. 49-65Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Several transportation factors concerning older and disabled people are under transition in Sweden at present. By the year 2010, the public transit system must be fully accessible for all passengers. The present survey studied older people, in order to assess the perceived travel opportunities. Questionnaires were sent to a sample of older citizens (75+) in three Swedish mid-sized municipalities. The general conclusions were that even though older people show appreciation of the existing travel opportunities, there was evidence for restricted mobility for some sub-groups of these older people, due to various perceived barriers. These groups have few optional modes, and despite various accessibility measures, special transportation services – the mandatory demand-responsive transport service – continues to provide crucial mobility. Hence, there is more to be done regarding accessibility and usability in public transit for older people. Further studies have to clarify reasons for bus travel cessation. Even larger efforts have to be put into accessibility improvements, in particular intermediate transit solutions in order to meet the regulations and policies.

  • 1055. Wägsäter, Dick
    et al.
    Löfgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of interleukin-17 in human colorectal cancer2006Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 26, nr 6B, s. 4213-4216Artikel i tidskrift (Refereegranskat)
  • 1056. Wågsater, Dick
    et al.
    Mumtaz, Melad
    Lofgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter -420C>G genotype.2008Ingår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, nr 10, s. 1008-1014Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.

  • 1057. Wågsäter, D
    et al.
    Sirsjö, A
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)2003Ingår i: Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, E-ISSN 1756-9966, Vol. 22, nr 3, s. 471-475Artikel i tidskrift (Övrigt vetenskapligt)
  • 1058. Wågsäter, Dick
    et al.
    Dienus, Olaf
    Löfgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Quantification of the chemokines CCL17 and CCL22 in human colorectal adenocarcinomas2008Ingår i: Molecular Medicine Reports, ISSN 1791-2997, Vol. 1, nr 2, s. 211-217Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Chemokines are believed to play a crucial role in local immunoresponse by regulating leukocyte movement in various tissues, including the intestinal mucosa. It has been suggested that they are key players in cancer biology, and several studies have identified leukocyte infiltration as a hallmark of most cancers. The chemokines CCL17 and CCL22 attract CCR4-bearing cells, which are especially polarised to Th2-type cells and regulatory T cells (Treg). Recent studies have revealed the participation of the CCL17 and CCL22 proteins in diseases such as atopic dermatitis and lymphoma. The purpose of this study was to assess the role of CCL17 and CCL22 protein expression in colorectal cancer (CRC) and to ascertain whether an association exists between promoter -431C>T CCL17 and -961G>A CCL22 gene polymorphisms in CRC versus non-CRC subjects. Using the ELISA assay, we noted a significantly higher expression of CCL22 in tumour tissue with a 2.3-fold up-regulation (tumour vs. paired normal tissue, n=78) but no significant difference in CCL17 protein expression. Immunohistochemistry revealed protein expression of CCL22 and CCL17 in the epithelial compartment of cancer tissue, in epithelial cells at the resection border that reflects normal tissue, and in some stromal cells such as lymphocytes, macrophages, and fibroblasts. Using a TaqMan system we screened for -431C>T CCL17 and -961G>A CCL22 gene variants in 245 CRC patients and 256 controls, but could not find any significant difference in genotype distribution or in allelic frequencies between the two groups. The genotype and allelic distributions of CRC patients were not related to tissue levels of CCL17 and CCL22 protein, and none of the variables were associated with plasma levels or clinical characteristics. To ascertain whether the tissue expression of CCL17 and CCL22 exerts an influence oil the pathogenesis of CRC, a forthcoming study oil the 5-year survival rate of CRC patients will be conducted.

  • 1059. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of chemokine receptor CXCR6 in human colorectal adenocarcinomas.2004Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 24, nr 6, s. 3711-3714Artikel i tidskrift (Refereegranskat)
  • 1060. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Hugander, Anders
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Sirsjö, Allan
    Ghaderi, Mehran
    Analysis of MICA gene transcripts in human rectal cancers2003Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 23, nr 3B, s. 2525-2529Artikel i tidskrift (Övrigt vetenskapligt)
  • 1061. Wågsäter, Dick
    et al.
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Sirsjö, Allan
    Induction of ATP-binding cassette A1 by all-trans retinoic acid: possible role of liver X receptor-alpha.2003Ingår i: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 11, nr 4, s. 419-423Artikel i tidskrift (Övrigt vetenskapligt)
  • 1062. Wågsäter, Dick
    et al.
    Hugander, Anders
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Expression of CXCL16 in human rectal cancer.2004Ingår i: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 14, nr 1, s. 65-69Artikel i tidskrift (Övrigt vetenskapligt)
  • 1063. Wågsäter, Dick
    et al.
    Jatta, Ken
    Ocaya, Pauline
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Sirsjo, Allan
    Expression of IL-1beta, IL-1 receptor type I and IL-1 receptor antagonist in human aortic smooth muscle cells: effects of all-trans-retinoic acid.2006Ingår i: Journal of Vascular Research, ISSN 1018-1172, E-ISSN 1423-0135, Vol. 43, nr 4, s. 377-382Artikel i tidskrift (Övrigt vetenskapligt)
  • 1064. Wågsäter, Dick
    et al.
    Löfgren, Sture
    Hugander, Anders
    Dienus, Olaf
    Dimberg, Jan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. Biomedicinsk plattform.
    Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine eotaxin-1 in colorectal cancer patients2007Ingår i: World Journal of Surgical Oncology, ISSN 1477-7819, E-ISSN 1477-7819, Vol. 5, s. 84-Artikel i tidskrift (Refereegranskat)
  • 1065.
    Xu, Z
    et al.
    Department of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, China.
    Qi, X
    Department of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, China.
    Dahl, Anna
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Xu, W
    Department of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, China.
    Waist-to-height ratio is the best indicator for undiagnosed Type 2 diabetes2013Ingår i: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 30, nr 6, s. e201-e207Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aims

    Early detection of diabetes is important for the prevention of diabetic complications. The best adiposity index for indicating Type 2 diabetes mellitus remains unclear. We aimed to identify the optimal adiposity measure among BMI, waist circumference, waist–hip ratio and waist-to-height ratio to indicate undiagnosed Type 2 diabetes and impaired fasting glucose in Chinese adults.

    Methods

    A total of 7567 participants aged 20–79 years were included in this study. Impaired fasting glucose was defined as a fasting plasma glucose level of 6.1–6.9 mmol/l in participants without diabetes. Undiagnosed Type 2 diabetes was identified as fasting plasma glucose ≥ 7.0 mmol/l when neither a history of diabetes nor use of hypoglycaemic drugs was present. Body weight, height, waist and hip circumferences were measured following standard procedures. Data were analysed using logistic regression and areas under the receiver operating characteristic curves.

    Results

    Of the 7567 participants, 536 were defined as having impaired fasting glucose and 690 were patients with Type 2 diabetes, including 290 (3.8%) persons with undiagnosed diabetes. In multivariate logistic regression, the odds ratios of waist-to-height ratio (≥ 0.5) were stronger than BMI (≥ 24 kg/m2), waist circumference (≥ 85 cm in men and ≥ 80 cm in women) and waist–hip ratio (≥ 0.85) for undiagnosed Type 2 diabetes and impaired fasting glucose. Among the four indices, waist-to-height ratio ≥ 0.5 showed the largest area under the receiver operating characteristic curve for diagnosing undiagnosed Type 2 diabetes (0.725, 95% CI 0.693–0.756) and impaired fasting glucose (0.662, 95% CI 0.638–0.687).

    Conclusions

    By comparison with BMI, waist circumference and waist–hip ratio, waist-to-height ratio ≥ 0.5 may be the best indicator for undiagnosed Type 2 diabetes and impaired fasting glucose.

  • 1066. Zarit, Steven H
    et al.
    Johansson, Boo
    Malmberg, Bo
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Changes in Functional Competency in the Oldest Old: A Longitudinal Study.1995Ingår i: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 7, nr 1, s. 3-23Artikel i tidskrift (Refereegranskat)
  • 1067. Zarit, Steven
    et al.
    Johansson, Boo
    Berg, Stig
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Functional impairment and co-disability in the oldest-old: A multidimensional approach1993Ingår i: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 5, nr 3, s. 291-305Artikel i tidskrift (Refereegranskat)
  • 1068. Zhang, H.
    et al.
    Xu, Weili
    Aging Research Center.
    Dahl, Anna
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi.
    Xu, Z.
    Wang, H-X.
    Qi, X.
    Relation of socio-economic status to impaired fasting glucose and Type 2 diabetes: findings based on a large population-based cross-sectional study in Tianjin, China2013Ingår i: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 30, nr 5, s. 157-162Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aims: Studies on the relationship between socio-economic status and Type 2 diabetes mellitus in the Chinese population are sparse. We aimed to examine the relation of socio-economic status as represented by income, education and occupation to impaired fasting glucose, Type 2 diabetes, and the control of Type 2 diabetes in a large Chinese population.

    Methods: This study included 7315 individuals who were aged 20-79 years and living in Tianjin, China. Impaired fasting glucose and Type 2 diabetes were ascertained according to the 1999 World Health Organization criteria. Data were analysed using multinomial and binary logistic regression, with adjustment for potential confounders.

    Result: Among all participants, 532 (7.3%) persons had impaired fasting glucose, 688 (9.4%) persons had Type 2 diabetes, including 288 (3.9%) previously undiagnosed Type 2 diabetes. In fully adjusted multinomial logistic regression, compared with higher income (≥ 2000 yuan, $243.3/month), lower income (< 1000 yuan, $121.70/month) showed odds ratios (95% confidence intervals) of 3.31 (2.48-4.41) for impaired fasting glucose, 4.50 (3.07-6.61) for undiagnosed Type 2 diabetes and 4.56 (3.20-6.48) for diagnosed Type 2 diabetes. These results remained significant in the analysis stratified by education and occupation. Furthermore, persons who were retired were more likely to have impaired fasting glucose [odds ratio 1.91 (1.40-2.45)], undiagnosed Type 2 diabetes [odds ratio 2.01) 1.40-2.89] and diagnosed Type 2 diabetes [odds ratio 3.02 (2.12-4.22)]. Among the patients with Type 2 diabetes previously diagnosed, lower education (less than senior high school), non-manual work and unemployment were related to worse glycaemic control (fasting blood glucose level > 8.5 mmol/l).

    Conclusions: Lower income and retirement are associated with increased odds of impaired fasting glucose and Type 2 diabetes in Tianjin, China. Education and occupation may play a role in glycaemic control among patients with Type 2 diabetes.

  • 1069. Åberg, AC
    et al.
    Sidenvall, Birgitta
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för omvårdnad. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Hepworth, M
    O'Reilly, K
    Lithell, H
    Continuity of the self in later life: perceptions of informal caregivers2004Ingår i: Qualitative Health Research, ISSN 1049-7323, E-ISSN 1552-7557, Vol. 14, nr 6, s. 792-815Artikel i tidskrift (Refereegranskat)
  • 1070.
    Åhnby, Ulla
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Forskningsplattformen socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. Äldres livsvillkor och omsorg.
    Österström, Stefan
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för beteendevetenskap och socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    To Age in Place: Experiences from Two Local Settings in Southern Sweden2002Ingår i: Aspects on aging, old age care and local contexts, Jönköping: Hälsohögskolan , 2002Kapitel i bok, del av antologi (Övrigt vetenskapligt)
19202122 1051 - 1070 av 1070
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