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  • 1051.
    Sindi, Shireen
    et al.
    Karolinska Inst, Solna, Stockholms Län, Sweden.
    Kiasat, Shadi
    Karolinska Inst, Solna, Stockholms Län, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Nilsen, Charlotta
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Psychosocial Working Conditions in Midlife And Cognitive and Physical Impairment in Older Age2022In: Innovation in Aging, E-ISSN 2399-5300, Vol. 6, no Supplement 1, p. 610-610Article in journal (Refereed)
    Abstract [en]

    Background: Psychosocial working conditions have been associated with cognitive and physical impairment among older adults. However, less is known on whether psychosocial working conditions are associated with a combination of cognitive and physical impairments. The aim of this study was to investigate the associations between midlife psychosocial working conditions and physical and cognitive impairment among older adults, and to assess whether there are sex differences in these associations. Methods: The data were derived from two Swedish nationally representative surveys (n=839) with a follow-up time of 20-24 years. Multinomial and binary logistic regressions were used to assess the associations between work stressors according to the job demand-control model, and a combination of cognitive and physical impairment. Results: Low control jobs were significantly associated with higher odds of both cognitive and physical impairment as well as a combination of cognitive and physical impairment. Passive jobs (low control, low demand) were associated with higher odds of cognitive impairment, and cognitive and physical impairment in combination. Active jobs (high control, high demand) were associated with lower odds of cognitive impairment. Sex-stratified analyses showed stronger associations among men than among women. Among men passive jobs were significantly associated with both cognitive and physical impairment. Low strain jobs were significantly associated with less physical impairment. Conclusions: These results highlight the importance of midlife psychosocial working conditions for late-life physical and cognitive impairment, and especially among men. Jobs characterised by higher control, lower strain and active jobs may promote resilience and cognitive reserve among older populations.

  • 1052.
    Sindi, Shireen
    et al.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Eskelinen, Marjo
    Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland.
    Hooshmand, Babak
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
    Lehtisalo, Jenni
    Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
    Soininen, Hilkka
    Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland.
    Ngandu, Tiia
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
    Kivipelto, Miia
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
    Healthy dietary changes in midlife are associated with reduced dementia risk later in life2018In: Nutrients, E-ISSN 2072-6643, Vol. 10, no 11, article id 1649Article in journal (Refereed)
    Abstract [en]

    Diet is an important modifiable lifestyle factor related to dementia risk. Yet, the role of midlife dietary changes is unclear. The goal is to investigate whether midlife healthy dietary changes are associated with late-life dementia risk. Data were collected within the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) population-based cohort study (n = 2000) (mean baseline age = 56 years). Participants returned for two late-life re-examinations (mean age = 70 and 78 years). Self-reported midlife diet was measured in a sub-sample (n = 341) (mean total follow-up = 16.8 years). Changes in specific dietary components (fats, vegetables, sugar, salt) were measured in midlife. Dementia diagnoses were ascertained with detailed examinations. Analyses adjusted for potential confounders. Total midlife healthy dietary changes (improving quality of fats, increasing vegetables, decreasing sugar and salt) were associated with a reduced risk of dementia (fully adjusted odds ratio (OR) 0.41, 95% confidence interval (CI) = 0.20–0.85). In contrast, when each factor was assessed individually, associations were not significant. This study is the first to show that beneficial midlife dietary changes are associated with a reduced dementia risk later in life. The results highlight the importance of targeting dietary patterns, where various food items may have synergistic effects. 

  • 1053.
    Sindi, Shireen
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Karolinska Inst, Stockholm, Sweden.
    Eskelinen, Marjo
    Univ Eastern, Joensuu, Finland.
    Hooshmand, Babak
    Karolinska Inst, Stockholm, Sweden.
    Soininen, Hilkka
    Univ Eastern, Joensuu, Finland.
    Ngandu, Tiia
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Kivipelto, Miia
    Karolinska Inst, Stockholm, Sweden.
    Healthy dietary changes in midlife are associated with a reduced dementia risk later in life2018In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 25, p. S167-S168Article in journal (Refereed)
  • 1054.
    Sindi, Shireen
    et al.
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Johansson, Lena
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden.
    Skoog, Johan
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden.
    Sjöberg, Linnea
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Wang, Hui-Xin
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Johansson, Boo
    Department of Psychology, Center for Health and Ageing AGECAP, University of Gothenburg, Sweden.
    Fratiglioni, Laura
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Soininen, Hilkka
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
    Solomon, Alina
    Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Skoog, Ingmar
    Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Sweden..
    Kivipelto, Miia
    Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, United Kingdom.
    Sleep disturbances and dementia risk: A multicenter study2018In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 10, p. 1235-1242Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk.

    METHODS: Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3-10 years follow-up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407).

    RESULTS: Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87-8.48).

    DISCUSSION: Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk.

  • 1055.
    Sindi, Shireen
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Karolinska Inst, Stockholm, Sweden.
    Ngandu, Tiia
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Hovatta, Iiris
    Univ Helsinki, Helsinki, Finland.
    Singh, Dhanna
    Alzheimers Res & Prevent Fdn, New York, NY USA.
    Wolozin, Benjamin
    Boston Univ, Boston, MA 02215 USA.
    Tuomilehto, Jaakko
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Soininen, Hilkka
    Univ Eastern, Kuopio, Finland.
    Soininen, Alina
    Univ Eastern, Kuopio, Finland.
    Effects of a multidomain lifestyle intervention on telomere length: The FINGER trial2018In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 25, p. S153-S154Article in journal (Refereed)
  • 1056.
    Sindi, Shireen
    et al.
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Solomon, Alina
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
    Hooshmand, Babak
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Soininen, Hilkka
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
    Kivipelto, Miia
    Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
    Midlife work-related stress is associated with late-life cognition2017In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 264, no 9, p. 1996-2002Article in journal (Refereed)
    Abstract [en]

    To investigate the associations between midlife work-related stress and late-life cognition in individuals without dementia from the general population. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study population (n = 2000) was randomly selected from independent Finnish population-based surveys (baseline mean age 50 years). Participants underwent two re-examinations in late life (mean age 71 and 78 years, respectively). 1511 subjects participated in at least one re-examination (mean total follow-up 25 years). Work-related stress was measured using two questions on work demands administered in midlife. Multiple cognitive domains were assessed. Analyses were adjusted for several potential confounders. Higher levels of midlife work-related stress were associated with poorer performance on global cognition [β-coefficient, -0.02; 95% confidence interval (CI), -0.05 to -0.00], and processing speed [β -0.03, CI -0.05 to -0.01]. Results remained significant after adjusting for potential confounders. Work-related stress was not significantly associated with episodic memory, executive functioning, verbal fluency or manual dexterity. This study shows that global cognition and processing speed may be particularly susceptible to the effects of midlife work-related stress.

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  • 1057.
    Sjölander, Per
    et al.
    Void Institute, Sweden.
    Lindström, Nina
    Southern Lapland Research Department, Sweden.
    Ericsson, AnnJessica
    Void Institute, Sweden.
    Kjellström, Sofia
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    A pattern recognition method for disclosing different levels of value system from questionnaire data2014In: Behavioral Development Bulletin, E-ISSN 1942-0722, Vol. 19, no 3, p. 112-125Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to describe, test and validate a method for disclosing significant response patterns from questionnaire data, and for classifying individual response profiles into a sequence of significant patterns. The method is based on pattern recognition statistics and probability calculations. The results from the population tested show that the method can disclose characteristic profiles of different value systems, and that these systems can be arranged in a hierarchical order similar to the conventional levels of ego development. It is suggested that this method is applicable to any multiple choice-questionnaire containing a number of items where the response alternatives represent a sequential order, for example, of different levels of development within a psychological domain. The method might be a valuable tool for acquiring information on the distribution of different levels of adult development in large populations, such as in communities and large organizations.

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  • 1058. Skoog, I
    et al.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Palmertz, B
    Andreasson, L-A
    The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds1996In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 93, no 2-3, p. 142-148Article in journal (Refereed)
  • 1059.
    Smailovic, U.
    et al.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, 14152, Sweden.
    Johansson, C.
    Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, 14152, Sweden.
    Koenig, T.
    Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, 3012, Switzerland.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Graff, C.
    Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, 14152, Sweden.
    Jelic, V.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, 14152, Sweden.
    Decreased global EEG synchronization in amyloid positive mild cognitive impairment and alzheimer’s disease patients: relationship to apoe ε42021In: Brain Sciences, ISSN 2076-3425, E-ISSN 2076-3425, Vol. 11, no 10, article id 1359Article in journal (Refereed)
    Abstract [en]

    The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer’s disease (AD) that has been linked to changes in brain structure and function as well as to different biological subtypes of the disease. The present study aimed to investigate the association of APOE ε4 genotypes with brain functional impairment, as assessed by quantitative EEG (qEEG) in patients on the AD continuum. The study population included 101 amyloid positive patients diagnosed with mild cognitive impairment (MCI) (n = 50) and AD (n = 51) that underwent resting-state EEG recording and CSF Aβ42 analysis. In total, 31 patients were APOE ε4 non-carriers, 42 were carriers of one, and 28 were carriers of two APOE ε4 alleles. Quantitative EEG analysis included computation of the global field power (GFP) and global field synchronization (GFS) in conventional frequency bands. Amyloid positive patients who were carriers of APOE ε4 allele(s) had significantly higher GFP beta and significantly lower GFS in theta and beta bands compared to APOE ε4 non-carriers. Increased global EEG power in beta band in APOE ε4 carriers may represent a brain functional compensatory mechanism that offsets global EEG slowing in AD patients. Our findings suggest that decreased EEG measures of global synchronization in theta and beta bands reflect brain functional deficits related to the APOE ε4 genotype in patients that are on a biomarker-verified AD continuum.

  • 1060.
    Smailovic, U.
    et al.
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Koenig, T.
    University of Bern, University Hospital of Psychiatry, Translational Research Center, Bern, Switzerland.
    Ashton, N. J.
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
    Winblad, B.
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden.
    Höglund, K.
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
    Nilsson, P.
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden.
    Zetterberg, H.
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
    Blennow, K.
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
    Jelic, V.
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden.
    Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's Disease2021In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 83, no 1, p. 355-366Article in journal (Refereed)
    Abstract [en]

    Background: Cerebrospinal fluid (CSF) neurogranin and quantitative electroencephalography (qEEG) are potential molecular and functional markers of synaptic pathology in Alzheimer's disease (AD). Synaptic markers have emerged as candidate prognostic indicators of AD since synaptic degeneration was shown to be an early event and the best correlate of cognitive deficits in patients along the disease continuum. Objective: The present study investigated the association between CSF neurogranin and qEEG measures as well as their potential to predict clinical deterioration in mild cognitive impairment (MCI) patients. Methods: Patients diagnosed with MCI (n=99) underwent CSF conventional AD biomarkers and neurogranin analysis and resting-state EEG recordings. The study population was further stratified into stable (n=41) and progressive MCI (n=31), based on the progression to AD dementia during two years follow-up. qEEG analysis included computation of global field power and global field synchronization in four conventional frequency bands. Results: CSF neurogranin levels were associated with theta power and synchronization in the progressive MCI group. CSF neurogranin and qEEG measures were significant predictors of progression to AD dementia, independent of baseline amyloid status in MCI patients. A combination of CSF neurogranin with global EEG power in theta and global EEG synchronization in beta band exhibited the highest classification accuracy as compared to either of these markers alone. Conclusion: qEEG and CSF neurogranin are independent predictors of progression to AD dementia in MCI patients. Molecular and neurophysiological synaptic markers may have additive value in a multimodal diagnostic and prognostic approach to dementia.

  • 1061.
    Smailovic, Una
    et al.
    Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
    Koenig, Thomas
    Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Centre, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Andersson, Thomas
    Department of Clinical Neurophysiology, Karolinska University Hospital, Huddinge, Sweden.
    Kramberger, Milica Gregoric
    Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
    Winblad, Bengt
    Alzheimer Research Center, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
    Jelic, Vesna
    Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
    Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers.2018In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 63, p. 88-95Article in journal (Refereed)
    Abstract [en]

    Synaptic dysfunction is the best anatomical correlate of early cognitive impairment in Alzheimer's disease (AD). Electroencephalography (EEG) directly reflects brain electrical activity at the level of synapses. The aim of the present study was to investigate correlations of quantitative EEG measures, global field power (GFP) and global field synchronization (GFS), with conventional cerebrospinal fluid (CSF) biomarkers of neurodegeneration in patients diagnosed with subjective cognitive decline (n = 210), mild cognitive impairment (n = 230), and AD (n = 197). Decreased CSF amyloid β42 significantly correlated with increased theta and delta GFP, whereas increased p- and t-tau with decreased alpha and beta GFP. Decreased CSF amyloid β42 and increased p- and t-tau were significantly associated with decreased GFS alpha and beta. Subanalysis of the separate diagnostic groups demonstrated significant correlations between CSF biomarkers and generalized power and synchronization already in the subjective cognitive decline and mild cognitive impairment group. These results provide evidence that quantitative EEG measures are associated and possibly sensitive to distinct AD-like CSF biomarker profiles in cognitively impaired patients and are therefore promising early noninvasive markers of AD.

  • 1062.
    Solomon, Alina
    et al.
    Karolinska institutet, Stockholm, Sweden.
    Enache, Daniela
    Karolinska institutet, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Karolinska institutet, Stockholm, Sweden.
    Kramberger, Milica
    Karolinska institutet, Stockholm, Sweden.
    Kivipelto, Miia
    Karolinska institutet, Stockholm, Sweden.
    Eriksdotter Jönhagen, Maria
    Div Clinical Geriatrics, Stockholm, Sweden.
    Aarsland, Dag
    Karolinska institutet, Stockholm, Sweden.
    Winblad, Bengt
    Karolinska institutet, Stockholm, Sweden.
    Jelic, Vesna
    Karolinska institutet, Stockholm, Sweden.
    Caide dementia risk score and cerebrospinal fluid Alzheimer biomarkers2014In: Alzheimer's & Dementia: the journal of the alzheimer's association, Elsevier, 2014, Vol. 10, p. 276-277Conference paper (Refereed)
  • 1063. Steen, Gunilla
    et al.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Sivik, L
    Steen, Bertil
    Cognitive function in 70-year-old men and women: A 16-year cohort difference population study1998In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 10, no 2, p. 120-126Article in journal (Refereed)
  • 1064. Steen, Gunilla
    et al.
    Fromholt, P
    Äystö, S
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Cognitive functioning in 75-year-olds: A study in three Nordic localities1997In: Functional status, health and aging: The NORA study, Paris: Serdi Publishing Co , 1997, p. 67-77Chapter in book (Other academic)
  • 1065. Steffenson, B
    et al.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    McClearn, Gerald E
    The importance of genetic and environmental effects for self-reported health symptoms: A 30 year follow-up considering survival and selection effects1999In: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 11, no 4, p. 475-493Article in journal (Refereed)
  • 1066.
    Steive, Karin
    et al.
    Department of Social Work and Criminology, University of Gävle, Gävle, Sweden.
    Tham, Pia
    Department of Social Work and Criminology, University of Gävle, Gävle, Sweden.
    Wiklund, Stefan
    Department of Social Work, Stockholm University, Stockholm, Sweden.
    Grell, Pär
    Department of Social Work and Criminology, University of Gävle, Gävle, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Studies on Integrated Health and Welfare (SIHW).
    Social work in an assembly line? The development of specialisation in child welfare and further internal division of work between 2003 and 20182023In: European Journal of Social Work, ISSN 1369-1457, E-ISSN 1468-2664Article in journal (Refereed)
    Abstract [en]

    Organisational specialisation characterises present social work in Sweden as internationally. Specialisation is often expected to lead to higher professional expertise. This study provides an overview of the development of specialisation and workforce characteristics in child welfare based on survey data collected in 2003, 2014 and 2018. The aim was to describe the development of specialisation and discuss the conditions for professional expertise in child welfare work. The results indicate that child welfare work is increasingly work task specialised. Social workers reported performing fewer tasks in 2014 and 2018 compared to 2003. This could be understood mainly as a form of statutory specialisation, indicating a shift in the professional role. Also, with the tendency to divide the work into only one or two phases of the process, child welfare work today almost resembles work at an assembly line. Compared with 2003, the statutory child welfare social workers surveyed in 2014 and 2018 were also significantly younger and less experienced. Since decision-making in child protection is a highly complex and challenging task, a question is if the development may be a survival strategy of the organisations rather than an opportunity for developing expertise.

  • 1067.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Finkel, Deborah
    Indiana University Sotheast, USA.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Genetic and environmental influences on longitudinal changes in functional biological age2015In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 45, no 6, p. 688-688Article in journal (Other academic)
  • 1068.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Kabir, Zarina N.
    Division of Nursing, NVS, Karolinska Institutet, Stockholm, Sweden.
    Hamadani, Jena D.
    International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh.
    Wahlin, Åke
    Department of Psychology, Stockholm University, Stockholm, Sweden.
    A cross-cultural perspective on aging and memory: Comparisons between Bangladesh and Sweden2012In: PsyCh Journal, ISSN 2046-0252, E-ISSN 2046-0260, Vol. 1, no 2, p. 69-81Article in journal (Refereed)
    Abstract [en]

    Most studies on cognitive aging have been conducted in high-income countries (mainly on Western populations). The main aim of this study was to compare the relative importance of predictors of episodic and semantic memory performance in older people (≥ 60years) from Bangladesh (n = 400) and Sweden (n = 1,098). Hierarchical regression models were used in order to study the importance of some commonly used predictors in the two countries. A main finding was that variations in age did not have much impact on episodic and semantic memory performance in Bangladesh. Instead, sex was a strong predictor for semantic memory performance. In Sweden this pattern was reversed. In the Western world, chronological age is believed to be strongly associated with memory performance in cross-sectional studies, particularly in people greater than 60 years of age. This study indicates that the difference between the two countries (in relative importance of the predictors included in this study) is mainly due to the fact that years of education is connected to age in the Western world but to sex in Bangladesh. It remains to be examined whether earlier selective survival is also responsible for the relative absence of cognitive age differences in Bangladesh.

  • 1069.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Lövdén, Martin
    Aging Research Center, Karolinska Institutet, Solna, Sweden.
    Kabir, Zarina N.
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
    Hamadani, Jena D.
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Different context but similar cognitive structures: Older adults in rural Bangladesh2016In: Journal of Cross-Cultural Gerontology, ISSN 0169-3816, E-ISSN 1573-0719, Vol. 31, no 2, p. 143-156Article in journal (Refereed)
    Abstract [en]

    Most research in cognitive aging is based on literate participants from high-income and Western populations. The extent to which findings generalize to low-income and illiterate populations is unknown. The main aim was to examine the structure of between-person differences in cognitive functions among elderly from rural Bangladesh. We used data from the Poverty and Health in Aging (PHA) project in Bangladesh. The participants (n = 452) were in the age range 60–92 years. Structural equation modeling was used to estimate the fit of a five-factor model (episodic recall, episodic recognition, verbal fluency, semantic knowledge, processing speed) and to examine whether the model generalized across age, sex, and literacy. This study demonstrates that an established model of cognition is valid also among older persons from rural Bangladesh. The model demonstrated strong (or scalar) invariance for age, and partial strong invariance for sex and literacy. Semantic knowledge and processing speed showed weak (or metric) sex invariance, and semantic knowledge demonstrated also sensitivity to illiteracy. In general, women performed poorer on all abilities. The structure of individual cognitive differences established in Western populations also fits a population in rural Bangladesh well. This is an important prerequisite for comparisons of cognitive functioning (e.g., declarative memory) across cultures. It is also worth noting that absolute sex differences in cognitive performance among rural elderly in Bangladesh differ from those usually found in Western samples.

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  • 1070.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Södertörn University, Huddinge, Sweden.
    Palmer, Katie
    Stockholm University, Sweden.
    Kabir, Zarina N.
    Karolinska Institutet, Stockholm, Sweden.
    Hasan, Mohammed I.
    International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Associations between functional biological age and cognition among older adults in rural Bangladesh: Comparisons with chronological age2019In: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 31, no 5, p. 814-836Article in journal (Refereed)
    Abstract [en]

    Objectives: We constructed a functional biological age (fBioAge) indicator by using four functional variables: grip strength, forced expiratory lung volume, visual acuity, and hearing. Our aim was to compare how chronological age (ChronAge) and fBioAge are related to cognitive abilities in older adults.

    Method: We used data from the Poverty and Health in Aging project, Bangladesh. Participants (N = 400) were 60+ years of age and diagnosed as nondemented. Examined cognitive abilities were four episodic memory measures (including recall and recognition), two verbal fluency indicators, two semantic knowledge, and two processing speed tasks.

    Results: fBioAge accounted for cognitive variance beyond that explained by ChronAge also after controlling for medical diagnoses and blood markers.

    Discussion: Compared with ChronAge, fBioAge was a stronger predictor of cognition during a broad part of the old adult span. fBioAge seems, in that respect, to have the potential to become a useful age indicator in future aging studies. 

  • 1071.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Reynolds, Chandra A.
    University of California, Riverside, CA, USA.
    Finkel, Deborah
    Department of Psychology, Indiana University Southeast, New Albany, IN, USA.
    Ernsth-Bravell, Marie
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Pedersen, Nancy L.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
    Dahl Aslan, Anna K.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Factors associated with grip strength decline in older adults2014In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 44, no 2, p. 269-274Article in journal (Refereed)
    Abstract [en]

    Background: few studies have examined associations of multi-faceted demographic, health and lifestyle factors with longterm change in grip strength performance across the adult lifespan. The aim of this study was to examine the associations of risk factors in specific parts of the adult lifespan (e.g. in early midlife, in late midlife and in old adulthood) separately for women and men.

    Methods: data came from the longitudinal Swedish Adoption/Twin Study of Aging (SATSA). Grip strength performance was followed in 849 participants who were 5088 years of age at baseline. The follow-up period with seven waves of data of grip strength was 22 years, and the risk factors were measured up to 20 years before the assessment of grip strength. Latent growth modelling was used for the longitudinal analyses.

    Results: a gender difference in the type of factors associated with grip strength performance and development across the adult lifespan was found. Significant factors for the age slopes for women were stress, smoking and dementia. For men, marital status, mean arterial pressure, physical activity at work and having a chronic disorder were of importance. These factors varied in their associations with grip strength across the adult lifespan.

    Conclusion: factors measured earlier in adulthood were associated with grip strength decline in late midlife and old adulthood. Gender-specific patterns of risk factors suggest that it may be worthwhile to conduct research on grip and muscle strength (and biological vitality) separately for men and women.

  • 1072.
    Sternäng, Ola
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Reynolds, Chandra A.
    Department of Psychology, University of California, Riverside.
    Finkel, Deborah
    4 Department of Psychology, Indiana University Southeast, New Albany.
    Ernsth-Bravell, Marie
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Pedersen, Nancy L
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
    Dahl Aslan, Anna K
    Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health. Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Grip Strength and Cognitive Abilities: Associations in Old Age2016In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368, Vol. 71, no 5, p. 841-848Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Both physical functioning and cognitive abilities are important for well-being, not least in old age. Grip strength is often considered an indicator of general vitality and, as such, may predict cognitive functioning. Few longitudinal studies have examined the relationship between grip strength and cognition, especially where specific cognitive abilities have been targeted.

    METHOD: Participants (n = 708, age range: 40-86 years at baseline) came from the population-based longitudinal Swedish Adoption/Twin Study of Aging. We used a longitudinal follow-up of 6 waves during 20 years. For the analyses, we used latent growth modeling, where latent growth trajectories were fitted to the cognitive traits (verbal ability, spatial ability, processing speed, and memory) or to the grip strength values and each, respectively, treated as time-varying covariates of the other trait.

    RESULTS: Results supported a longitudinal influence of grip strength on changes in cognitive function. Grip strength performance was associated with change in the 4 cognitive abilities after age 65 years.

    DISCUSSION: A rather stable connection was found between grip strength and cognitive abilities starting around 65 years of age. The starting period suggests that the association may be due to lifestyle changes, such as retirement, or to acceleration of the aging processes.

  • 1073.
    Ståhl, Ylva
    et al.
    Jönköping University, School of Health and Welfare, HHJ. CHILD.
    Enskär, Karin
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Nursing Science. Jönköping University, School of Health and Welfare, HHJ. CHILD.
    Almborg, Ann-Helene
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Granlund, Mats
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health and Welfare, HHJ. CHILD. Jönköping University, School of Education and Communication, HLK, CHILD.
    Contents of Swedish school health questionnaires2011In: British Journal of School Nursing, ISSN 1752-2803, Vol. 6, no 2, p. 82-88Article in journal (Refereed)
    Abstract [en]

    Aim: This study aims to analyse and link the content of the health information requested in questionnaires used locally in Swedish child and school health services. Background: In industrialized countries, children's health needs are changing from physical to psychosocial needs and the questionnaires used for health screening and guiding health promotion must therefore adapt to these changes. Methods: Questionnaires were analysed, together with health items linked to the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY). The inter-rater agreement for linking was 80%. Standard age groups were used to improve the comparability across different questionnaires. Results: The information requested for the youngest children focused on communication and acquiring language. For the children aged 6 years and above, health questionnaires related to mental functions, the school situation, psychosomatic symptoms and issues associated with taking care of one's health. Conclusions: The information relating to health in questionnaires revealed that interest focused on health items strongly related to the different age groups and to psychosocial health. The focus was the child as a person rather than the child within a family and school environment.

  • 1074.
    Subic, Ana
    et al.
    Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
    Cermakova, Pavla
    National Institute of Mental Health, Klecany, Czech Republic.
    Religa, Dorota
    Polish Academy of Sciences, Mossakowski Medical Research Center, Warsaw, Poland.
    Han, Shuang
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    von Euler, Mia
    Department of Medicine-Solna, Karolinska Institutet, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Johnell, Kristina
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Fastbom, Johan
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Bognandi, Liselia
    Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
    Winblad, Bengt
    Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.
    Kramberger, Milica G
    Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
    Eriksdotter, Maria
    Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
    Garcia-Ptacek, Sara
    Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
    Treatment of Atrial Fibrillation in Patients with Dementia: A Cohort Study from the Swedish Dementia Registry2018In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 61, no 3, p. 1119-1128Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Patients with dementia might have higher risk for hemorrhagic complications with anticoagulant therapy prescribed for atrial fibrillation (AF).

    OBJECTIVE: This study assesses the risks and benefits of warfarin, antiplatelets, and no treatment in patients with dementia and AF.

    METHODS: Of 49,792 patients registered in the Swedish Dementia Registry 2007-2014, 8,096 (16%) had a previous diagnosis of AF. Cox proportional hazards models were used to calculate the risk for ischemic stroke (IS), nontraumatic intracranial hemorrhage, any-cause hemorrhage, and death.

    RESULTS: Out of the 8,096 dementia patients with AF, 2,143 (26%) received warfarin treatment, 2,975 (37%) antiplatelet treatment, and 2,978 (37%) had no antithrombotic treatment at the time of dementia diagnosis. Patients on warfarin had fewer IS than those without treatment (5.2% versus 8.7%; p < 0.001) with no differences compared to antiplatelets. In adjusted analyses, warfarin was associated with a lower risk for IS (HR 0.76, CI 0.59-0.98), while antiplatelets were associated with increased risk (HR 1.25, CI 1.01-1.54) compared to no treatment. For any-cause hemorrhage, there was a higher risk with warfarin (HR 1.28, CI 1.03-1.59) compared to antiplatelets. Warfarin and antiplatelets were associated with a lower risk for death compared to no treatment.

    CONCLUSIONS: Warfarin treatment in Swedish patients with dementia is associated with lower risk of IS and mortality, and a small increase in any-cause hemorrhage. This study supports the use of warfarin in appropriate cases in patients with dementia. The low percentage of patients on warfarin treatment indicates that further gains in stroke prevention are possible.

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  • 1075.
    Sundberg, Fredrika
    et al.
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.
    Fridh, Isabell
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.
    Lindahl, Berit
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Associations between healthcare environment design and adverse events in intensive care unit2021In: Nursing in Critical Care, ISSN 1362-1017, E-ISSN 1478-5153, Vol. 26, no 2, p. 86-93Article in journal (Refereed)
    Abstract [en]

    Background: Healthcare environment can affect health. Adverse events (AEs) are common because rapid changes in the patients' status can suddenly arise, and have serious consequences, especially in intensive care. The relationship between the design of intensive care units (ICUs) and AEs has not been fully explored. Hence, an intensive care room was refurbished with cyclic lightning, sound absorbents and unique interior, and exterior design to promote health. Aims: The aim of this study was to evaluate the differences between a regular and a refurbished intensive care room in risk for AEs among critically ill patients. Design: This study retrospectively evaluated associations of AEs and compared the incidence of AEs in patients who were assigned to a multidisciplinary ICU in a refurbished two-bed patient room with patients in the control rooms between 2011 and 2018. Methods: There were 1938 patients included in this study (1382 in control rooms; 556 in the intervention room). Descriptive statistics were used to present the experienced AEs. Binary logistic regressions were conducted to estimate the relationship between the intervention/control rooms and variables concerning AEs. Statistical significance was set at P < 0.05. Results: For the frequency of AEs, there were no significant differences between the intervention room and the control rooms (10.6% vs 11%, respectively, P < 0.805). No findings indicated the intervention room (the refurbished room) had a significant influence on decreasing the number of experienced AEs in critically ill patients. Conclusions: The findings revealed a low incident of AEs in both the intervention room as well as in the control rooms, lower than previously described. However, our study did not find any decreases in the AEs due to the design of the rooms. Relevance to clinical practice: Further research is needed to determine the relationship between the physical environment and AEs in critically ill patients.

  • 1076.
    Sundberg, Fredrika
    et al.
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Sweden.
    Fridh, Isabell
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Sweden.
    Lindahl, Berit
    Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Visitor’s Experiences of an Evidence-Based Designed Healthcare Environment in an Intensive Care Unit2021In: Health Environments Research & Design Journal, ISSN 1937-5867, E-ISSN 2167-5112, Vol. 14, no 2, p. 178-191Article in journal (Refereed)
    Abstract [en]

    Objectives: The objective of the research was to study the visitors’ experiences of different healthcare environment designs of intensive care unit (ICU) patient rooms.

    Background: The healthcare environment may seem frightening and overwhelming in times when life-threatening conditions affect a family member or close friend and individuals visit the patient in an ICU. A two-bed patient room was refurbished to enhance the well-being of patients and their families according to the principles of evidence-based design (EBD). No prior research has used the Person-centred Climate Questionnaire—Family version (PCQ-F) or the semantic environment description (SMB) in the ICU setting.

    Methods: A sample of 99 visitors to critically ill patients admitted to a multidisciplinary ICU completed a questionnaire; 69 visited one of the two control rooms, while 30 visited the intervention room.

    Results: For the dimension of everydayness in the PCQ-F, a significantly better experience was expressed for the intervention room (p <.030); the dimension regarding the ward climate general was also perceived as higher in the intervention room (p <.004). The factors of pleasantness (p <.019), and complexity (p < 0.049), showed significant differences favoring the intervention room in the SMB, with borderline significance on the modern factor (p <.061).

    Conclusion: Designing and implementing an enriched healthcare environment in the ICU setting increases person-centered care in relation to the patients’ visitors. This could lead to better outcomes for the visitors, for example, decreasing post-traumatic stress disorder symptoms, but this needs further investigations.

  • 1077.
    Sundgren, M.
    et al.
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Piehl, Fredrik
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Brismar, Tom
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Cognitive function did not improve after initiation of natalizumab treatment in relapsing-remitting multiple sclerosis. A prospective one-year dual control group study2016In: Multiple Sclerosis and Related Disorders, ISSN 2211-0348, E-ISSN 2211-0356, Vol. 10, p. 36-43Article in journal (Refereed)
    Abstract [en]

    Background: Cognitive impairment in multiple sclerosis (MS) is common and has severe implications. Natalizumab (NZ) has documented effects on relapse rate and radiological disease activity in relapsing-remitting MS (RRMS) but studies regarding its specific effects on cognitive functioning are few. Previous studies have reported improvement, however, often lacking relevant control groups. The objective of the present study was to evaluate the cognitive effects of NZ treatment, compared to patients on stable first-line treatment and healthy control subjects.

    Methods: MS patients starting NZ (MS-NZ), MS controls with stable interferon beta therapy (MS-C) and healthy control subjects (HC) were evaluated twice with one year interval, using a cognitive test battery covering six cognitive domains. The effects of NZ on levels of self-reported depression, fatigue, daytime sleepiness and perceived health were also examined.

    Results: MS patients (MS-NZ and MS-C) had significantly lower baseline cognitive performance compared to HC (global score, p=0.002), but there were no significant differences between MS-NZ and MS-C. At follow-up, both MS-NZ and MS-C had improved significantly in four and five cognitive domains, respectively, and in global score (p=0.013 and p<0.001, respectively). HC improved significantly in three cognitive domains but not in global score. A regression analysis including baseline cognitive z-score and z-score change showed that participants with lower baseline scores had a significantly greater improvement, compared to those with better initial performance (p=0.021). There were no significant changes in depression, fatigue, daytime sleepiness or perceived health in MS-NZ or MS-C.

    Conclusions: Initiation of NZ therapy did not result in true cognitive improvement over one year. Presumably, the increased test performance in both MS groups was artificial and due to retest effects that were stronger in patients with lower baseline performance. Adequate control groups are essential when evaluating cognitive functioning in intervention trials among RRMS patients.

  • 1078.
    Sundgren, Mathias
    et al.
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Nikulin, Vadim V.
    Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité – University Medicine Berlin, Germany.
    Maurex, Liselotte
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Piehl, Fredrik
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Brismar, Tom
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    P300 amplitude and response speed relate to preserved cognitive function in relapsing–remitting multiple sclerosis2015In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 126, no 4, p. 689-697Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE:

    To explore if cognitive impairment in relapsing-remitting multiple sclerosis (RRMS) is associated with abnormal neural function and if there is evidence of neural compensatory mechanisms.

    METHODS:

    Seventy-two RRMS patients and 89 healthy control subjects were included in a cross-sectional study. Event-related brain potential (P300) and response time (RT) were recorded with visual and auditory choice reaction tasks. Cognitive function was evaluated with an 18 item test battery.

    RESULTS:

    Patients had a decrease in cognitive function (p<0.001 for global score) and increased visual P300 amplitude frontally. P300 amplitude was normal in other brain areas and RT was normal. P300 latency was normal except for an increase in auditory latency occipitally. Cognitive performance correlated positively with parietal P300 amplitude in patients but not in controls. Cognition had stronger correlation (negative) with RT in patients than in controls.

    CONCLUSIONS:

    Patients with low P300 amplitude and long RT were more often cognitively impaired. This indicates that general factors such as signal amplitude and speed are limiting for cognitive function in RRMS patients. The increase in frontal P300 amplitude may be a compensatory effect.

    SIGNIFICANCE:

    Our findings suggest that high amplitude and fast speed may be protective against cognitive impairment.

  • 1079.
    Sundgren, Mathias
    et al.
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Wahlin, Åke
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Maurex, Liselotte
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Brismar, Tom
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Event related potential and response time give evidence for a physiological reserve in cognitive functioning in relapsing-remitting multiple sclerosis2015In: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 356, no 1-2, p. 107-112Article in journal (Refereed)
    Abstract [en]

    Cognitive dysfunction is common in multiple sclerosis (MS). Different factors may moderate the degree of cognitive deficit. The aim of the present study was to distinguish different mechanisms for cognitive reserve in relapsing–remitting MS (RRMS). The effects of clinical variables (physical disability, depression), premorbid intelligence (years of education, vocabulary knowledge), visual event-related potentialmeasures (P300) and response time(RT)were studied in RRMS patients (n=71) and healthy subjects (n=89). Patients with high P300 amplitude and short RT had better cognitive performance. This effect was significantly weaker in controls. High P300 and short RT may be physiological markers of a cognitive reserve in RRMS. In contrast, the association between cognitive scores and premorbid intelligence was similar in patients and in control subjects. The effects of physiological reserve and clinical variables were studied in a hierarchical linear regression model of cognitive performance in RRMS. P300 amplitude and RT explained a considerable amount of variance in global cognitive performance (34%, p b 0.001). The effects of P300 and RTwere notmoderated by premorbid intelligence. Physical disability and depression added significantly to explained variance, and the final model accounted for 44%  (p b 0.001) of the variation. We conclude that physiological reserve is the strongest moderator of cognitive impairment in RRMS

  • 1080.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    100 Years of Coresidence. The Case of the Younger Generation in Sweden1984Report (Other (popular scientific, debate etc.))
  • 1081.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    15 000 guldbröllop2002In: Välfärdsbulletinen, ISSN 0280-1418, no 2, p. -17Article in journal (Other (popular science, discussion, etc.))
  • 1082.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    A Haven in a Heartless World?: Living with Parents in Sweden and the United States, 1880-19821987In: Continuity and Change, ISSN 0268-4160, E-ISSN 1469-218X, Vol. 2, no 1, p. 145-187Article in journal (Refereed)
  • 1083.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Ageing is riskier than it looks (Commentary).1995In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 24, no 5, p. 373-374Article in journal (Refereed)
  • 1084.
    Sundström, Gerdt
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. SALVE (Social challenges, Actors, Living conditions, reseach VEnue).
    Alla dessa skandaler som kom och gick - inte visste jag att det var omsorg2016In: Äldre i centrum, ISSN 1401-5110, no 1, p. 72-75Article in journal (Other (popular science, discussion, etc.))
  • 1085.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Arvet efter morfar och Gorbatjovs favoritförfattare1991In: Aldring & Eldre, ISSN 0801-9991, no 3, p. 21-23Article in journal (Other academic)
  • 1086.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Assisted Living for our parents: A son's journey.2008In: Ageing & Society, Vol. 3, p. 435-437Article, book review (Other (popular science, discussion, etc.))
  • 1087.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Att förlora ett litet barn2012In: Välfärd, ISSN 1651-6710, 1654-1502, Vol. 31, no 1, p. 28-29Article in journal (Other academic)
    Abstract [en]

    This article describes infant mortality in Sweden 1749-2010 both from the perspective of the chidren and - less well known - from that of the parents: How big was/is the risk for parents to lose one or more children? Data from the 1935/36 special census and the Generational Records of Statistics Sweden suggest that the average risk for parents to lose one or more of their infants was about 67 % in the 1700s, 18 % in the early 1900s and less than one percent today.

  • 1088.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Behov av vård och omsorg: en kunskapsöversikt1999Report (Other (popular science, discussion, etc.))
  • 1089.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Bestandsaufnahmen und Perspektiven der Schwedischen Alterfürsorge1988In: 20. Fachtagung, Wohlfartswerk für Baden-Württemberg, 9/1987, 1988Conference paper (Other scientific)
  • 1090.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Besök i ålderdomen2005In: Aldring og livsløp, ISSN 1503-0849, no 3, p. 30-31Article, book review (Other (popular science, discussion, etc.))
  • 1091.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Biographies and Potentials Influence1994In: Older Women in Europe, Copenhagen/ DanAge, Feb 24-25, 1994Conference paper (Other scientific)
  • 1092.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Bo hemma på äldre da’r2000Report (Other (popular science, discussion, etc.))
  • 1093.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Bokanmälan: Gripande levnadsporträtt av värmlänningar & Minnesbok från Dalarna2002In: Äldre i Centrum, ISSN 1653-3585, no 1, p. 44-45Article, book review (Other (popular science, discussion, etc.))
  • 1094.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Bokanmälan; Tor Inge Romörens Den fjerde alderen.: Funksjonstap, familjeomsorg og tjenstebruk hos mennesker over 80 år.2002In: Tidsskrift for velferdsforskning, ISSN 0809-2052, E-ISSN 2464-3076, Vol. 5, no 1, p. 53-56Article, book review (Other (popular science, discussion, etc.))
  • 1095.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Bor inte alla japanska gamlingar med sina barn?: Nya mönster ny framtid!1994In: PRO-Pensionären, ISSN 0345-9225, no 7, p. 48-50Article in journal (Other (popular science, discussion, etc.))
  • 1096.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Care by Families: An Overview of Trends1994In: Caring for Frail Elderly People: New Directions in Care, Paris: OECD , 1994Chapter in book (Other academic)
  • 1097.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Caring for the Aged in Welfare Society1983Doctoral thesis, comprehensive summary (Other academic)
  • 1098.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Changing Family and Household Structures of Western Elderly: A Comparison of Implications for Care1993In: The XVth Congress of the International Association of Gerontology, July 4-9, Budapest, 1993Conference paper (Other scientific)
  • 1099.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Community Care of the Aged in Scandinavia1985Report (Other (popular scientific, debate etc.))
  • 1100.
    Sundström, Gerdt
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    De gamla, deras anhöriga och hemtjänsten: en studie av gränslandet mellan informell och formell omsorg1984Report (Other (popular science, discussion, etc.))
19202122232425 1051 - 1100 of 1409
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