Change search
Refine search result
1 - 1 of 1
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Högberg, Gustav
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Karlsson, Pontus
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Detektion och kvantifiering av två olika isoformer av PDIA3 i prostatacancerceller2019Independent thesis Basic level (professional degree), 180 HE creditsStudent thesis
    Abstract [en]

    There is a need for more specific biomarkers related to prostate cancer, which would increase treatment options. Different isoforms of protein disulfide isomerase family A, member 3 (PDIA3) are associated with prostate cancer and can potentially be used as biomarkers. The aims of this study were to detect, quantify and examine the gene expression of the protein coding isoform PDIA3-201 and a newly discovered isoform of PDIA3 (PDIA3-Novel) in prostate cancer cells in varying stages. The expression was analysed using droplet digital Polymerase Chain Reaction (ddPCR) in normal prostate cells and in prostate cancer cell lines (PNT2, DU145, PC3 and LNCaP). Variation within replicates and between different dilutions were observed. The ratio of concentrations between PDIA3-Novel and PDIA3-201 differed both within and between the cell lines. The expression of PDIA3-Novel was higher in PNT2 and PC3 compared to DU145. The expression of PDIA3-Novel was higher in the metastatic stage of prostate cancer (LNCaP), but the flaws in the study reduces the reliability of the results. The results of this study indicate that PDIA3-Novel can be used as a biomarker for prostate cancer and provide information beneficial for treatment. More experiments on a larger scale needs to be performed.

1 - 1 of 1
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf