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  • 1.
    Berg, Stig
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Dahl, Anna
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Cognitive decline and dementia2007In: Geropsychology: European perspectives for an aging world, Cambridge, Mass.: Hogrefe & Huber , 2007, p. 165-182Chapter in book (Other (popular science, discussion, etc.))
  • 2.
    Dahl, Anna
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Health factors and cognitive functioning in old age2006In: 18. Nordiska Kongressen i Gerontologi, Jyväskylä, 2006Conference paper (Refereed)
  • 3.
    Dahl, Anna
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Nilsson, Sven
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Identification of dementia in epidemiological research: A study on the usefulness of various data sources2007In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 19, no 5, p. 381-389Article in journal (Refereed)
    Abstract [en]

    Background and aims: Prevalence and incidence ratios of dementia in epidemiological studies vary according to the data source used. Medical records, cognitive tests, and registry information are sources frequently used to differentiate dementia from normal aging. The aim of the present study was to compare the identification of dementia from these different sources with that from consensus diagnosis. 

    Methods: 498 elderly people (age range 70–81 at baseline) enrolled in a Swedish population-based longitudinal twin study (Gender) were evaluated on physical and mental health and interviewed for their socio-demographic background three times during an eight-year period. Reviews of medical records and the Swedish Discharge Registry (DR) were conducted. The 10th percentile was used to differentiate between dementia and non-dementia in all cognitive tests. Scores of 24 or below on the Mini-Mental State Examination (MMSE) (range 1–30) indicated dementia. A consensus conference diagnosed dementia on the basis of total information. The consensus diagnosis was used as the gold standard. 

    Results: MMSE scores (sensitivity 64%, specificity 96%, kappa 0.65) and the review of medical records (sensitivity 57%, specificity 99%, kappa 0.65) were good sources for dementia identification. The precision of medical records increased when recordings of cognitive impairment were included (sensitivity 83%, specificity 98%, kappa 0.84). The discharge registry had low sensitivity (26%) and kappa coefficient (0.31). 

    Conclusions: The present study shows that both review of medical records and MMSE scores are good although not perfect identifiers of dementia. The discharge registry is an uncertain source of dementia identification.

  • 4. Evrin, Per-Erik
    et al.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Öberg, Tommy
    Malmberg, Bo
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Serum C-reactive protein in elderly men and women: Association with mortality, morbidity, and various biochemical values.2005In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 65, no 1, p. 23-31Article in journal (Refereed)
  • 5. Gold, Carol
    et al.
    Rovine, Michael
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Malmberg, Bo
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerhald
    Gender and Patterns of Cardiovascular Diagnoses and Year of Diagnoses in an Unlike-Sex Twin Sample in Sweden2007In: Gerontological Society of America 60th Annual Scientific Meeting, 2007Conference paper (Refereed)
  • 6. Gold, Carol
    et al.
    Rovine, Michel
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Malmberg, Bo
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Gender and patterns of cardiovascular diagnoses in an unlike-sex twin sample in Sweden2007In: The Gerontological Society of America, 60th Annual Scientific Meeting, San Francisco, 2007, p. 68-Conference paper (Refereed)
    Abstract [en]

    Gender and Patterns of Cardiovascular Diagnoses and Year of Diagnoses in an Unlike-Sex Twin Sample in Sweden

    Cardiovascular disease is the number one cause of death for men and women. This study examined diagnoses in health records in a sample of older-unlike-sex twins in Sweden (N=249 pairs). A physician in Sweden has examined these twins’ medical records going back as far as 50 years and compiled a database with diagnoses based on ICD-10 codes and the year of diagnosis. A subsample of twinpairs was created in which both members had been diagnosed with at least one cardiovascular condition (N=140 pairs). The number of these conditions ranged from 1-8, with men having more than women (chi-square = 15.349, 7 d.f., p<.05). Analyses of the 4 most frequent conditions were conducted. We found 59 subjects with a diagnosis of myocardial infarction (45 men; 14 women), but only 4 concordant twinpairs; of those 2 brothers preceded their sister in year of diagnosis. We found 72 cases of congestive heart failure (43 men; 29 women), but only 12 concordant twinpairs; in half of those cases, the brother preceded his sister. We found 61 cases of stroke (34 men; 27 women), but only 12 concordant twinpairs; in 5 cases the brother preceded his sister. We found 181 subjects with arterial hypertension (77 men; 104 women), and 66 concordant twinpairs; in 31 of those twinpairs, the brother preceded his sister, and in 35 the sister preceded her brother. Additional pattern analyses will be presented that describe the arrays of cardiovascular co-morbidities and their year of diagnosis within twinpairs and the whole sample.

    Benefits and Learning Objectives

    To present pattern analyses of cardiovascular conditions in an unlike-sex twin sample

  • 7. Gottsäter, A
    et al.
    Samuelsson, U
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Lernmark, Å
    Sundkvist, G
    Islet cell antibodies and fasting plasma C-peptide during the first 10 year after diagnosis in patients with diabetes mellitus diagnosed in adult age1992In: Diabetes, Nutrition and Metabolism. Clinical and Experimental, ISSN 0394-3402, E-ISSN 1720-8343, Vol. 5, no 4, p. 243-248Article in journal (Refereed)
  • 8. Hassing, Linda B
    et al.
    Grant, M D
    Hofer, Scott M
    Pedersen, Nancy L
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Johansson, Boo
    Type 2 diabetes mellitus contributes to cognitive decline in old age: A longitudinal population-based study2004In: Journal of the International Neuropsychological Society, ISSN 1355-6177, E-ISSN 1469-7661, Vol. 10, no 4, p. 599-607Article in journal (Refereed)
  • 9. Hassing, Linda B
    et al.
    Hofer, Scott M
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Pedersen, Nancy L
    McClearn, Gerald
    Johansson, Boo
    Comorbid Hypertension and Type 2 Diabetes Mellitus Exacerbates Cognitive Decline: Evidence from a Longitudinal Study2004In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 33, no 4, p. 355-361Article in journal (Refereed)
  • 10. Hassing, Linda B
    et al.
    Johansson, Boo
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Pedersen, Nancy L
    Hofer, Scott M
    McClearn, Gerald
    Terminal decline and markers of cerebro- and cardiovascular disease: Findings from a longitudinal study of the oldest old2002In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368, Vol. 57, no 3, p. P268-P276Article in journal (Refereed)
  • 11. Hassing, Linda B
    et al.
    Johansson, Boo
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Pedersen, Nancy L
    Gatz, Margret
    McClearn, Gerald
    Diabetes Mellitus Is a Risk Factor for Vascular Dementia, but Not for Alzheimer's Disease: A population-based study of the oldest old2002In: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203X, Vol. 14, no 3, p. 239-248Article in journal (Refereed)
  • 12. Hassing, Linda B
    et al.
    Johansson, Boo
    Pedersen, Nancy L
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Type 2 Diabetes Mellitus and Cognitive Performance in a Population-Based Sample of the Oldest Old: Impact of Comorbid Dementia2003In: Aging, Neuropsychology and Cognition, ISSN 1382-5585, E-ISSN 1744-4128, Vol. 10, no 2, p. 99-107Article in journal (Refereed)
  • 13.
    Malmberg, Bo
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Nilsson, Sven E
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Fransson, Eleonor
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Brismar, Kerstin
    Increased Serum Prolactin in Elderly is Associated with Worse Subjective Health, Higher Risk of Dementia and Impaired Survival2008In: 19th Nordic Congress of Gerontology, 2008Conference paper (Other (popular science, discussion, etc.))
  • 14.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Genetic and constitutional aspects of diabetes mellitus1962Doctoral thesis, monograph (Other scientific)
  • 15.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Aspirin and Alzheimer's disease protection2006In: Oxidative Stress and Age-Related Neurodegeneration, Boca Raton: Taylor & Francis , 2006, p. 159-180Chapter in book (Other (popular science, discussion, etc.))
  • 16.
    Nilsson, Sven E.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Anders Andersson: bortglömd medlem av Svenska akademien.2006In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, no 37, p. 2678-2679Article in journal (Other (popular science, discussion, etc.))
  • 17.
    Nilsson, Sven E.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Frida Kahlo suffered probably of post-polio syndrome.2004In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 101, no 46, p. 3696-3697Article in journal (Refereed)
  • 18.
    Nilsson, Sven E.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Pulserande elektromagnetiska fält och placebo gav samma effekt2008In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 105, no 32-33, p. 2167-2170Article in journal (Other (popular science, discussion, etc.))
  • 19.
    Nilsson, Sven E
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Johansson, Boo
    Zarit, Steven
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Melander, E
    Does aspirin protect against alzheimer's dementia?: A study in a Swedish population-based sample aged ≥80 years2003In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 59, no 4, p. 313-319Article in journal (Refereed)
  • 20.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Evrin, Per-Erik
    Tryding, Nils
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
    Johansson, Boo
    Biochemical values in persons older than 82 years of age: report from a population-based study of twins2003In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 63, no 1, p. 1-14Article in journal (Refereed)
  • 21.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Brismar, Kerstin
    Karolinska Institutet.
    Relationship between serum progesterone concentrations and cardiovascular disease, diabetes, and mortality in elderly Swedish men and women: An 8-year prospective study2009In: Gender Medicine, ISSN 1550-8579, Vol. 6, no 3, p. 433-443Article in journal (Refereed)
  • 22.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Karlsson, David
    McClearn, Gerald
    A comparison of diagnosis capture from medical records, self-reports, and drug regristration: A study in individuals 80 years and older2002In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 14, p. 178-184Article in journal (Refereed)
  • 23.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. HHJ. Ageing - living conditions and health.
    Ockander, L
    Dolby, J
    Åstrand, B
    A computer in the physician´s consultancy1983Book (Refereed)
  • 24.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Takkinen, Sanna
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Mellander, Arne
    Lindblad, U
    Low systolic blood pressure is associated with impaired cognitive function in the oldest old: Longitudinal observations in a population-based sample 80 years and older2007In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 19, no 1, p. 41-47Article in journal (Refereed)
  • 25.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Takkinen, Sanna
    Johansson, Boo
    Dotevall, G
    Mellander, Arne
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    McClearn, Gerald
    Laxative treatment elevates plasma homocysteine: A study on a population-based Swedish sample of old people2004In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 60, no 1, p. 45-49Article in journal (Refereed)
  • 26.
    Nilsson, Sven
    et al.
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Takkinen, Sanna
    Tryding, Nils
    Ervin, Per-Erik
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Association of biochemical values with morbidity in the elderly: a population-based Swedish study of persons aged 82 or more years2003In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 63, no 7-8, p. 457-466Article in journal (Refereed)
  • 27. Takkinen, Sanna
    et al.
    Gold, Carol
    Pedersen, Nancy L
    Malmberg, Bo
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Nilsson, Sven
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Rovine, Michael
    Gender differences in depression: a study of older unlike-sex twins.2004In: Aging & Mental Health, ISSN 1360-7863, E-ISSN 1364-6915, Vol. 8, no 3, p. 187-195Article in journal (Refereed)
  • 28.
    Wikby, Anders
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Månsson, Ingrid A.
    Johansson, Boo
    Strindhall, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Nilsson, Sven E.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.2008In: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 9, no 5, p. 299-308Article in journal (Refereed)
    Abstract [en]

    Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.

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