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  • 1. Andersson, P O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J O
    Influence of insulin pen injection frequency on quality of life1990In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 13, no 11, p. 1135-1136Article in journal (Refereed)
  • 2. Andersson, P. O.
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J. O.
    Pen injection and change in metabolic control and quality of life in insulin dependent diabetes mellitus1997In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 36, no 3, p. 169-172Article in journal (Refereed)
    Abstract [en]

    A second follow-up of metabolic control and quality of life in insulin dependent diabetes mellitus (IDDM) patients who had switched 3 years before from syringe to multiple pen injection treatment, was carried out. A total of 73 consecutive outpatients were enrolled in the initial follow-up study in 1988, 1 year after their changeover to insulin pen, with their metabolic control and quality of life examined. The present study concerns the reexamination of 65 of them in 1990. Their HbA(1c) level was recorded yearly, already from 1987, on. After an enhancement of metabolic control in 1988, exhibited primarily by patients with fewer syringe injections before pen treatment, control up to 1990 was found to have regressed to about baseline level or to have gradually declined. Patients who perceived their ability to self-test blood glucose to have decreased exhibited the least satisfactory course of metabolic control. This is seen to indicate that maintaining self-testing in multiple injection insulin treatment is a very real challenge to this regimen.

  • 3. Cherfan, Pierre
    et al.
    Tompa, Andrea
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Löfgren, Sture
    Jonasson, Lena
    Effects of simvastatin on human T cells in vivo2007In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 193, no 1, p. 186-192Article in journal (Refereed)
  • 4. DelaRosa, Olga
    et al.
    Pawelec, Graham
    Peralbo, Esther
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Mariani, Erminia
    Mocchegiani, Eugenio
    Tarazona, Raquel
    Solana, Rafael
    Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity.2006In: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 7, no 5-6, p. 471-481Article in journal (Refereed)
  • 5. Ferguson, F G
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Maxson, P
    Olsson, J
    Johansson, B
    Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors.1995In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 50, no 6, p. B378-B382Article in journal (Refereed)
  • 6. Forsey, R J
    et al.
    Thompson, J M
    Ernerudh, J
    Hurst, T L
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Johansson, B
    Nilsson, B-O
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Plasma cytokine profiles in elderly humans.2003In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 124, no 4, p. 487-493Article in journal (Refereed)
  • 7. Fulop, Tamas
    et al.
    Larbi, Anis
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Mocchegiani, Eugenio
    Hirokawa, Katsuiku
    Pawelec, Graham
    Dysregulation of T-cell function in the elderly: scientific basis and clinical implications.2005In: Drugs & Aging, ISSN 1170-229X, E-ISSN 1179-1969, Vol. 22, no 7, p. 589-603Article in journal (Refereed)
  • 8. Fülöp, Tamas
    et al.
    Larbi, Anis
    Hirokawa, Katsuiku
    Mocchegiani, Eugenio
    Lesourds, Bruno
    Castle, Stephen
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Franceschi, Claudio
    Pawelec, Graham
    Immunosupportive therapies in aging2007In: Clinical Interventions in Aging, ISSN 1176-9092, Vol. 2, no 1, p. 33-54Article in journal (Refereed)
  • 9. Hadrup, Sine Reker
    et al.
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Køllgaard, Tania
    Seremet, Tina
    Johansson, Boo
    Pawelec, Graham
    thor Straten, Per
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.2006In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 176, no 4, p. 2645-2653Article in journal (Refereed)
  • 10. Hyland, Paul
    et al.
    Duggan, Orla
    Turbitt, Julie
    Coulter, James
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Tompa, Andrea
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Barnett, Christopher
    Barnett, Yvonne
    Nonagenarians from the Swedish NONA Immune Study have increased plasma antioxidant capacity and similar levels of DNA damage in peripheral blood mononuclear cells compared to younger control subjects2002In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 37, no 2-3, p. 465-473Article in journal (Refereed)
  • 11. Hörnquist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Dufva, A M
    Insulin-pen treatment, quality of life and metabolic control: retrospective intra-group evaluations.1990In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 10, no 3, p. 221-230Article in journal (Refereed)
  • 12. Hörnquist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hansson, B
    Andersson, P O
    Quality of life: status and change (QLsc) reliability, validity and sensitivity of a generic assessment approach tailored for diabetes.1993In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 2, no 4, p. 263-279Article in journal (Refereed)
  • 13. Hörnqvist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Change in quality of life along with type 1 diabetes.1995In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 28, no 1, p. 63-72Article in journal (Refereed)
  • 14. Hörnqvist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Akerlind, I
    Type II diabetes and quality of life: a review of the literature.1995In: PharmacoEconomics (Auckland), ISSN 1170-7690, E-ISSN 1179-2027, Vol. 8, no Suppl 1, p. 12-16Article in journal (Refereed)
  • 15. Jonasson, L
    et al.
    Tompa, Andrea
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Expansion of peripheral CD8+ T cells in patients with coronary artery disease: relation to cytomegalovirus infection.2003In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 254, no 5, p. 472-478Article in journal (Refereed)
  • 16. Jonasson, L
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Olsson, A G
    Low serum beta-carotene reflects immune activation in patients with coronary artery disease2003In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 13, no 3, p. 120-125Article in journal (Refereed)
  • 17. Jonasson, Lena
    et al.
    Linderfalk, Carina
    Olsson, Jadwiga
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Olsson, Anders G
    Systemic T-cell activation in stable angina pectoris.2002In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 89, no 6, p. 754-756Article in journal (Refereed)
  • 18. Koch, Sven
    et al.
    Larbi, Anis
    Ozcelik, Dennis
    Solana, Rafael
    Gouttefangeas, Cécile
    Attig, Sebastian
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Franceschi, Claudio
    Pawelec, Graham
    Cytomegalovirus infection: a driving force in human T cell immunosenescence.2007In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, no 1114, p. 23-35Article in journal (Refereed)
  • 19. Nijm, Johnny
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Tompa, Andrea
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Olsson, Anders G
    Jonasson, Lena
    Circulating levels of proinflammatory cytokines and neutrophil-platelet aggregates in patients with coronary artery disease.2005In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 95, no 4, p. 452-456Article in journal (Refereed)
  • 20. Nilsson, Bengt-Olof
    et al.
    Ernerudh, Jan
    Johansson, Boo
    Evrin, Per-Eric
    Löfgren, Sture
    Ferguson, Frederick G
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols.2003In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 124, no 4, p. 469-476Article in journal (Refereed)
  • 21. Nilsson, Bengt-Olof
    et al.
    Skogh, Thomas
    Ernerudh, Jan
    Johansson, Boo
    Löfgren, Sture
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Dahle, Charlotte
    Antinuclear antibodies in the oldest-old women and men2006In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 27, no 4, p. 281-288Article in journal (Refereed)
  • 22. Ouyang, Qin
    et al.
    Wagner, Wolfgang M
    Voehringer, David
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Klatt, Tatjana
    Walter, Steffen
    Müller, Claudia A
    Pircher, Hanspeter
    Pawelec, Graham
    Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)2003In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 38, no 8, p. 911-920Article in journal (Refereed)
  • 23. Ouyang, Qin
    et al.
    Wagner, Wolfgang M
    Walter, Steffen
    Müller, Claudia A
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Aubert, Geraldine
    Klatt, Tatjana
    Stevanovic, Stefan
    Dodi, Tony
    Pawelec, Graham
    An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness2003In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 124, no 4, p. 477-485Article in journal (Refereed)
  • 24. Ouyang, Qin
    et al.
    Wagner, Wolfgang M
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Remarque, Ed
    Pawelec, Graham
    Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?2003In: European Cytokine Network, ISSN 1148-5493, E-ISSN 1952-4005, Vol. 13, no 4, p. 392-394Article in journal (Refereed)
  • 25. Ouyang, Qin
    et al.
    Wagner, Wolfgang M
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Walter, Steffen
    Aubert, Geraldine
    Dodi, Anthony I
    Travers, Paul
    Pawelec, Graham
    Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old2003In: Journal of Clinical Immunology, ISSN 0271-9142, E-ISSN 1573-2592, Vol. 23, no 4, p. 247-257Article in journal (Refereed)
  • 26. Ouyang, Qin
    et al.
    Wagner, Wolfgang M
    Zheng, Wei
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Remarque, Ed J
    Pawelec, Graham
    Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly.2004In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 39, no 4, p. 607-613Article in journal (Refereed)
  • 27. Pawelec, G
    et al.
    Ferguson, F G
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    The SENIEUR protocol after 16 years.2001In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 122, no 2, p. 132-134Article in journal (Other academic)
  • 28. Pawelec, G
    et al.
    Koch, S
    Franceschi, C
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Human immunosenescence: does it have an infectious component?2006In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1067, p. 56-65Article in journal (Refereed)
  • 29. Pawelec, Graham
    et al.
    Akbar, Arne
    Caruso, Calogero
    Effros, Rita
    Grubeck-Loebenstein, Beatrix
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Is immunosenescence infectious?2004In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 25, no 8, p. 406-410Article in journal (Refereed)
  • 30. Pawelec, Graham
    et al.
    Akbar, Arne
    Caruso, Calogero
    Solana, Rafael
    Grubeck-Loebenstein, Beatrix
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Human immunosenescence: is it infectious?2005In: Immunological Reviews, ISSN 0105-2896, E-ISSN 1600-065X, Vol. 205, p. 257-268Article in journal (Refereed)
  • 31. Pawelec, Graham
    et al.
    Derhovanessian, Evelyna
    Larbi, Anis
    Strindhall, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Wikby, Anders
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Cytomegalovirus and human immunosenescence2009In: Reviews in Medical Virology, ISSN 1052-9276, E-ISSN 1099-1654, Vol. 19, no 1, p. 47-56Article, review/survey (Refereed)
    Abstract [en]

    'Immunosenescence' is all imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. Primarily anecdotal evidence implies that failing immunity is responsible for the increased incidence and severity of infectious disease in old people. However, there is a serious dearth of accurate hard data concerning the actual cause of death in the elderly and the contribution thereto of the multitude of age-associated alterations measured in the immune system. Cross-sectional studies comparing those currently young With those currently old reveal a large number of differences in the distribution of immune cell types in the blood, and to some extent the functional integrity of those cells. Many of these parameters differ markedly between individuals infected with CMV and uninfected people, regardless of infection with other persistent herpesviruses. The adaptive arm of immunity appears to be more seriously affected than the innate arm, particularly the T lymphocytes. However, cross-sectional studies suffer the disadvantage that like is not being compared with like, because the conditions applied during the entire life course of the currently elderly were different from those applied now to the young. These differences in environment, nutrition, pathology and possibly genetics, rather than merely age, may be expected to influence the parameters studied. Moreover, pathogen exposure of the currently elderly was also different from contemporary exposure, probably including CMV. Some of the problems associated with cross-sectional studies can be overcome by performing longitudinal studies, as pointed out in an earlier analysis of the Baltimore Longitudinal Ageing study looking at lymphocyte numbers. However, longitudinal studies are challenging in humans. L Nonetheless, the pioneering Swedish OCTO/NONA studies of the very elderly which for the first time included a range of immune parameters, have identified a set of immune parameters predicting mortality at 2, 4 and 6 year follow-up; CMV infection makes a material contribution to this so-called immune risk profile (IRP)'. Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review. 

  • 32. Pawelec, Graham
    et al.
    Koch, Sven
    Gouttefangeas, Cécile
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Immunorejuvenation in the elderly2006In: Rejuvenation Research, ISSN 1549-1684, Vol. 9, no 1, p. 111-116Article in journal (Refereed)
  • 33. Pawelec, Graham
    et al.
    Ouyang, Qin
    Wagner, Wolfgang
    Biol, Dipl
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Pathways to a robust immune response in the elderly2003In: Immunology and allergy clinics of North America, ISSN 0889-8561, E-ISSN 1557-8607, Vol. 23, no 1, p. 1-13Article in journal (Refereed)
  • 34. Ross, Owen A.
    et al.
    Hyland, Paul
    Curran, Martin D.
    McIlhatton, Brian P.
    Wikby, Anders
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Tompa, Andrea
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Pawelec, Graham
    Barnett, Christopher R.
    Middleton, Derek
    Barnett, Yvonne A.
    Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?2002In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 37, no 2-3, p. 329-340Article in journal (Refereed)
    Abstract [en]

    An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of mtDNA4977 and the accumulation of point mutations with age. A competitive polymerase chain reaction (PCR) methodology incorporating three primers was used to detect and quantify the levels of mtDNA4977 and a novel heteroduplex reference strand conformational analysis (RSCA) technique was used to analyse the accumulation of point mutations. The assays were applied to an in vitro model of T cell ageing and ex vivo DNA samples from an elderly cohort of subjects and a younger control group. The mtDNA4977 was detected in all the DNA samples examined but only a very low concentration was observed and no age-related increase or accumulation was observed. No accumulation of point mutations was identified using RSCA within the T cell clones as they were aged or the ex vivo lymphocytes from the elderly cohort. A higher level of variation was observed within the ex vivo DNA samples, verifying the high resolution of RSCA and its ability to identify different mtDNA species, although no correlation with age was observed. The low level of mtDNA damage observed with respect to the ex vivo lymphocyte DNA samples within this study may be due in part to the high turnover of blood cells/mtDNA, which may inhibit the accumulation of genetically abnormal mtDNA that may play a role in immunosenescence. A similar explanation may also apply to the in vitro model of T cell ageing if the vast majority of the cells are replicating rather than entering senescence.

  • 35. Roth, G
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. CHILD.
    Nilsson, L
    Thalén, A
    High-performance liquid chromatographic determination of epimers, impurities, and content of the glucocorticoid budesonide and preparation of primary standard.1980In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 69, no 7, p. 766-770Article in journal (Refereed)
  • 36. Ryrfeldt, A
    et al.
    Tönnesson, M
    Nilsson, E
    Wikby, A
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. CHILD.
    Pharmacokinetic studies of a potent glucocorticoid (budesonide) in dogs by high-performance liquid chromatography.1979In: Journal of Steroid Biochemistry, ISSN 0022-4731, Vol. 10, no 3, p. 317-324Article in journal (Refereed)
  • 37.
    Stenström, Ulf
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P.O.
    Rydén, O.
    Relationship between locus of control beliefs and metabolic control in insulin-dependent diabetes mellitus1998In: British Journal of Health Psychology, ISSN 1359-107X, E-ISSN 2044-8287, Vol. 3, no 1, p. 15-25Article in journal (Refereed)
  • 38.
    Stenström, Ulf
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnqvist, J O
    Andersson, P O
    Recent life events, gender, and the control of diabetes mellitus.1993In: General Hospital Psychiatry, ISSN 0163-8343, E-ISSN 1873-7714, Vol. 15, no 2, p. 82-88Article in journal (Refereed)
  • 39.
    Stenström, Ulf
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnqvist, J O
    Andersson, P O
    Recent life events, gender differences, and the control of insulin-dependent diabetes mellitus: A 2-year follow-up study.1995In: General Hospital Psychiatry, ISSN 0163-8343, E-ISSN 1873-7714, Vol. 17, no 6, p. 433-439Article in journal (Refereed)
  • 40.
    Strindhall, Jan
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Löfgren, Sture
    Division of Medical Diagnostics, Ryhov County Hospital, Jönköping, Sweden.
    Främsth, Caroline
    Division of Medical Diagnostics, Ryhov County Hospital, Jönköping, Sweden.
    Matussek, Andreas
    Division of Medical Diagnostics, Ryhov County Hospital, Jönköping, Sweden.
    Bengner, Malin
    Department of Infectious Diseases, Ryhov County Hospital, Jönköping, Sweden.
    Ernerudh, Jan
    Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Wikby, Anders
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    CD4/CD8 ratio < 1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study2017In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 95, p. 82-87Article in journal (Refereed)
  • 41.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Ferguson, Frederick
    Forsey, Rosalyn
    Thompson, Julie
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Löfgren, Sture
    Nilsson, Bengt-Olof
    Ernerudh, Jan
    Pawelec, Graham
    Johansson, Boo
    An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.2005In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 60, no 5, p. 556-565Article in journal (Refereed)
  • 42.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J O
    Andersson, P O
    Background, quality of life and metabolic control in patients with insulin-dependent diabetes mellitus.1991In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 13, no 1-2, p. 53-61Article in journal (Refereed)
  • 43.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnqvist, J O
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Background factors, long-term complications, quality of life and metabolic control in insulin dependent diabetes.1993In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 2, no 4, p. 281-286Article in journal (Refereed)
  • 44.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, B
    Ferguson, F
    Olsson, J
    Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study1994In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 29, no 5, p. 531-41Article in journal (Refereed)
  • 45.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Olsson, Jadwiga
    Löfgren, Sture
    Nilsson, Bengt Olof
    Ferguson, Frederick
    Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study.2002In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 37, no 2-3, p. 445-453Article in journal (Refereed)
  • 46.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Maxson, P
    Olsson, J
    Johansson, B
    Ferguson, F G
    Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study.1998In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 102, no 2-3, p. 187-198Article in journal (Refereed)
  • 47.
    Wikby, Anders
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Månsson, Ingrid A.
    Johansson, Boo
    Strindhall, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Nilsson, Sven E.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.2008In: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 9, no 5, p. 299-308Article in journal (Refereed)
    Abstract [en]

    Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.

  • 48.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Nilsson, Bengt-Olof
    Forsey, Rosalyn
    Thompson, Julie
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Löfgren, Sture
    Ernerudh, Jan
    Pawelec, Graham
    Ferguson, Frederick
    Johansson, Boo
    The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning.2006In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 127, no 8, p. 695-704Article in journal (Refereed)
  • 49.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Hörnquist, J
    Metabolic control, quality of life, and negative life events: a longitudinal study of well-controlled and poorly regulated patients with type 1 diabetes after changeover to insulin pen treatment.1998In: The diabetes educator, ISSN 0145-7217, E-ISSN 1554-6063, Vol. 24, no 1, p. 61-66Article in journal (Refereed)
  • 50.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J O
    Andersson, P O
    Coping behaviour and degree of discrepancy between retrospective and prospective self-ratings of change in quality of life in type 1 diabetes mellitus1993In: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 10, no 9, p. 851-854Article in journal (Refereed)
1 - 50 of 50
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