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  • 1. Bassan, Gioia
    et al.
    Larsson, David
    KTH, Medicinsk bildteknik.
    Nordenfur, Tim
    KTH, Medicinsk bildteknik.
    Bjällmark, Anna
    KTH, Medicinsk bildteknik.
    Larsson, Matilda
    KTH, Medicinsk bildteknik.
    Acquisition of multiple mode shear wave propagation in transversely isotropic medium using dualprobe setup2015Konferensbidrag (Refereegranskat)
  • 2.
    Maksuti, Elira
    et al.
    KTH, Medicinsk bildteknik.
    Widman, Erik
    KTH, Medicinsk bildteknik.
    Larsson, David
    KTH, Medicinsk bildteknik.
    Urban, Matthew W.
    Larsson, Matilda
    KTH, Medicinsk bildteknik.
    Bjällmark, Anna
    KTH, Medicinsk bildteknik.
    Arterial stiffness estimation by shear wave elastography: Validation in phantoms with mechanical testing2016Ingår i: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 42, nr 1, s. 308-321Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Arterial stiffness is an independent risk factor found to correlate with a wide range of cardiovascular diseases. It has been suggested that shear wave elastography (SWE) can be used to quantitatively measure local arterial shear modulus, but an accuracy assessment of the technique for arterial applications has not yet been performed. In this study, the influence of confined geometry on shear modulus estimation, by both group and phase velocity analysis, was assessed, and the accuracy of SWE in comparison with mechanical testing was measured in nine pressurized arterial phantoms. The results indicated that group velocity with an infinite medium assumption estimated shear modulus values incorrectly in comparison with mechanical testing in arterial phantoms (6.7 +/- 0.0 kPa from group velocity and 30.5 +/- 0.4 kPa from mechanical testing). To the contrary, SWE measurements based on phase velocity analysis (30.6 +/- 3.2 kPa) were in good agreement with mechanical testing, with a relative error between the two techniques of 8.8 +/- 6.0% in the shear modulus range evaluated (40-100 kPa). SWE by phase velocity analysis was validated to accurately measure stiffness in arterial phantoms.

  • 3.
    Widman, Erik
    et al.
    KTH, Medicinsk bildteknik.
    Maksuti, Elira
    KTH, Medicinsk bildteknik.
    Larsson, David
    KTH, Medicinsk bildteknik.
    Urban, M.
    Caidahl, K.
    KTH, Medicinsk teknik.
    Bjällmark, Anna
    KTH, Medicinsk bildteknik.
    Larsson, Matilda
    KTH, Medicinsk bildteknik.
    Feasibility of shear wave elastography for plaque characterization2014Ingår i: IEEE International Ultrasonics Symposium, IUS, 2014, s. 1818-1821Konferensbidrag (Refereegranskat)
    Abstract [en]

    Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with atherosclerotic plaque in the common carotid artery and quantitative characterization methods are needed. In this study, shear wave elastography (SWE) was used to characterize soft plaque mimicking inclusions in three atherosclerotic arterial phantoms by using phase velocity analysis in a static environment. The results were validated with axial tensile mechanical testing (MT). SWE measured a mean shear modulus of 5.8 ± 0.3 kPa and 25.0 ± 1.2 kPa versus 3.0 kPa and 30.0 kPa measured by mechanical testing in the soft plaques and phantom walls respectively. The results show good agreement between MT and SWE for both the plaque and phantom wall.

  • 4.
    Widman, Erik
    et al.
    KTH, Medicinsk bildteknik.
    Maksuti, Elira
    KTH, Medicinsk bildteknik.
    Larsson, David
    KTH, Medicinsk bildteknik.
    Urban, M W
    Bjällmark, Anna
    KTH, Medicinsk bildteknik.
    Larsson, Matilda
    KTH, Medicinsk bildteknik.
    Shear wave elastography plaque characterization with mechanical testing validation: a phantom study.2015Ingår i: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 60, nr 8, s. 3151-3174Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with atherosclerotic plaque. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and new quantitative methods are needed. In this study, shear wave elastography (SWE) was used to characterize hard and soft plaque mimicking inclusions in six common carotid artery phantoms by using phase velocity analysis in static and dynamic environments. The results were validated with mechanical tensile testing. In the static environment, SWE measured a mean shear modulus of 5.8±0.3kPa and 106.2±17.2kPa versus 3.3±0.5kPa and 98.3±3.4kPa measured by mechanical testing in the soft and hard plaques respectively. Furthermore, it was possible to measure the plaques' shear moduli throughout a simulated cardiac cycle. The results show good agreement between SWE and mechanical testing and indicate the possibility for in vivo arterial plaque characterization using SWE.

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