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  • 1.
    Olsen, Renate Slind
    et al.
    Department of Laboratory Medicine, Division of Medical Diagnostics, Region Jönköping County, Jönköping, Sweden.
    Dimberg, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Geffers, Robert
    Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
    Wågsäter, Dick
    Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
    Possible role and therapeutic target of PDGF-D signalling in colorectal cancer2019In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, no 2, p. 99-112Article in journal (Refereed)
    Abstract [en]

    Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.

  • 2. Wågsater, Dick
    et al.
    Mumtaz, Melad
    Lofgren, Sture
    Hugander, Anders
    Dimberg, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter -420C>G genotype.2008In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, no 10, p. 1008-1014Article in journal (Refereed)
    Abstract [en]

    A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.

  • 3.
    Wågsäter, Dick
    et al.
    Karolinska Institute.
    Löfgren, Sture
    Ryhov County Hospital.
    Zar, Niklas
    Ryhov County Hospital.
    Hugander, Anders
    Ryhov County Hospital.
    Dimberg, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Pigment epithelium-derived factor expression in colorectal cancer patients2010In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 28, no 8, p. 872-877Article in journal (Refereed)
1 - 3 of 3
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