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  • 1. Bohmova, K
    et al.
    Cerny, M
    Hladikova, Z
    Vrabelova, Z
    Stadlerova, G
    Kverka, M
    Spalova, I
    Chudoba, D
    Pithova, P
    Zacharovova, K
    Brabec, R
    Faresjö, Maria
    Hälsouniversitetet i Linköping.
    Stechova, K
    Cord blood cytokine profile detection in neonates with T1D parents: monitoring of cellular auto-reactivity using protein microarray2007In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 66, no 5, p. 563-571Article in journal (Refereed)
  • 2.
    Karlsson Faresjö, Maria
    et al.
    Hälsouniversitet i Linköping.
    Ernerudh, J
    Ludvigsson, J
    Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes2004In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 59, no 5, p. 517-526Article in journal (Refereed)
  • 3.
    Karlsson Faresjö, Maria
    et al.
    Hälsouniversitetet i Linköping.
    Ludvigsson, J
    Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes2005In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 61, no 2, p. 173-179Article in journal (Refereed)
  • 4. Matussek, A
    et al.
    Strindhall, Jan
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Stark, L
    Rohde, M
    Geffers, R
    Buer, J
    Kihlström, E
    Lindgren, P-E
    Löfgren, S
    Infection of human endothelial cells with Staphylococcus aureus induces transcription of genes encoding an innate immunity response.2005In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 61, no 6, p. 536-544Article in journal (Refereed)
  • 5. Michalek, J
    et al.
    Vrabelova, Z
    Hrotekova, Z
    Kyr, M
    Pejchlova, M
    Kolouskova, S
    Faresjö, Maria
    Hälsouniversitetet i Linköping.
    Stechova, K
    Hälsouniversitetet i Linköping.
    Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus2006In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 64, no 5, p. 531-535Article in journal (Refereed)
  • 6. Stechova, K
    et al.
    Spalovat, I
    Durilova, M
    Baratskovat, M
    Cernys, M
    Cerena, M
    Pithova, D
    Chudoba, D
    Ullmanova, T
    Faresjö, Maria
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Influence of maternal hyperglycaemia on cord blood mononuclear cells in response to diabetes-associated autoantigens2009In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 70, p. 149-158Article in journal (Refereed)
    Abstract [en]

    Perfect maternal diabetes compensation is crucial for the outcome of the baby. However, little is known how hyperglycaemia influences the specific immune response. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effect of maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Populations: (1) Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester: perfect (= 15) or acceptable (= 25) compensation. (2) newborns with T1D father (= 12) (3) newborns with a mother treated for either gestational or type 2 diabetes (= 10) (4) control newborns (= 25). Spontaneous as well as diabetes-associated autoantigen-stimulated production of 23 cytokines and chemokines were tested using protein microarray. In addition, the influence of glucose on cytokine and chemokine responsiveness was analyzed in vitro. The study groups differed in their spontaneous as well as stimulated cytokine and chemokine spectra. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers (= 0.001) and also in mothers with perfect diabetes compensation during the 3rd trimester (= 0.016) in comparison with control newborns. By contrast, cord blood mononuclear cells cultivated in vitro in high glucose concentration decreased the diabetogenic stimulated Th1 cytokine response. Maternal ‘sweet’ as well as ‘autoimmune environment’ may both lead to lower occurrence of T1D within their offspring. Further studies will reveal the exact immunological mechanism of this observation.

  • 7.
    Strindhall, Jan
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Lindgren, P-E
    Löfgren, S
    Kihlström, E
    Clinical isolates of Staphylococcus aureus vary in ability to stimulate cytokine expression in human endothelial cells.2005In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 61, no 1, p. 57-62Article in journal (Refereed)
  • 8.
    Strindhall, Jan
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Lundblad, A
    Påhlsson, P
    Interferon-gamma enhancement of E-selectin expression on endothelial cells is inhibited by monensin1997In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 46, no 4, p. 338-343Article in journal (Refereed)
1 - 8 of 8
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