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  • 1. Andersson, P. O.
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J. O.
    Pen injection and change in metabolic control and quality of life in insulin dependent diabetes mellitus1997In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 36, no 3, p. 169-172Article in journal (Refereed)
    Abstract [en]

    A second follow-up of metabolic control and quality of life in insulin dependent diabetes mellitus (IDDM) patients who had switched 3 years before from syringe to multiple pen injection treatment, was carried out. A total of 73 consecutive outpatients were enrolled in the initial follow-up study in 1988, 1 year after their changeover to insulin pen, with their metabolic control and quality of life examined. The present study concerns the reexamination of 65 of them in 1990. Their HbA(1c) level was recorded yearly, already from 1987, on. After an enhancement of metabolic control in 1988, exhibited primarily by patients with fewer syringe injections before pen treatment, control up to 1990 was found to have regressed to about baseline level or to have gradually declined. Patients who perceived their ability to self-test blood glucose to have decreased exhibited the least satisfactory course of metabolic control. This is seen to indicate that maintaining self-testing in multiple injection insulin treatment is a very real challenge to this regimen.

  • 2. Hörnquist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Dufva, A M
    Insulin-pen treatment, quality of life and metabolic control: retrospective intra-group evaluations.1990In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 10, no 3, p. 221-230Article in journal (Refereed)
  • 3. Hörnqvist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Change in quality of life along with type 1 diabetes.1995In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 28, no 1, p. 63-72Article in journal (Refereed)
  • 4.
    Karlsson, Maria
    et al.
    Hälsouniversitetet i Linköping.
    Ludvigsson, J
    Determination of mRNA expression for IFN-y and IL-4 in lymphocytes from children with IDDM by RT-PCR technique1998In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 40, no 1, p. 21-30Article in journal (Refereed)
  • 5.
    Karlsson, Maria
    et al.
    Hälsouniversitetet i Linköping.
    Ludvigsson, J
    The ABBOS-peptide from bovine serum albumin causes an IFN-y and IL-4 mRNA respose in lymphocytes from children with recent onset of type 1 diabetes2000In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 47, no 3, p. 199-207Article in journal (Refereed)
  • 6.
    Rydén, Anna
    et al.
    Division of Paediatrics & Diabetes Research Centre, Department of Clinical & Experimental Medicine, Faculty of Health Sciences, Linköping University.
    Faresjö, Maria
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Altered immune profile from pre-diabetes to manifestation of type 1 diabetes2013In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 100, no 1, p. 74-84Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:While the mechanisms leading to β-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneously and following stimulation with the autoantigens GAD65, and HSP60, at high-risk and T1D onset and further to 8 months post diagnosis.

    METHODS:Fifteen first-degree relatives of T1D patients with a high risk of developing the disease within five years, 25 children approximately four days and 8 months after diagnosis of T1D and 16 healthy children were included in the study. Cytokines (IL-1β, -6, -7, -10, -13, -17, IFN-γ and TNF-α) and chemokines (CCL2, -3, -4, -5 and CXCL10) associated with Th1, Th2, Tr1 and inflammatory cells were detected in cell culture supernatants by Luminex-technique, and markers associated with regulatory T-cells (FOXP3, CTLA-4 and TGF-β) by real-time RT-PCR.

    RESULTS:High-risk individuals differed in immunity from that seen in healthy and T1D children. High-risk individuals had a low TNF-α response and fewer responders from mitogen exposure as well as low spontaneous secretions of IL-13 compared to healthy children. High-risk individuals that later developed T1D, had a lower FOXP3 and CTLA-4 mRNA expression, following stimulation with GAD65, in combination with higher secretion of the pro-inflammatory chemokine CCL4.

    CONCLUSION:Changes in immunity seen in individuals with high risk of developing T1D points to alterations/actions in the immune system already early in the pre-diabetic phase.

  • 7.
    Stenström, Ulf
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work.
    Andersson, P
    Smoking, blood glucose control, and locus of control beliefs in people with type 1 diabetes mellitus.2000In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 50, no 2, p. 103-107Article in journal (Refereed)
  • 8.
    Stenström, Ulf
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work.
    Göth, Alvar
    Carlsson, Christina
    Andersson, Per-Olof
    Stress management training as related to glycemic control and mood in adults with Type 1 diabetes mellitus.2003In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 60, no 3, p. 147-152Article in journal (Refereed)
  • 9.
    Wikby, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hörnquist, J O
    Andersson, P O
    Background, quality of life and metabolic control in patients with insulin-dependent diabetes mellitus.1991In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 13, no 1-2, p. 53-61Article in journal (Refereed)
1 - 9 of 9
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