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  • 1.
    Vasilopoulos, Terrie
    et al.
    Department of Biobehavioral Health, The Pennsylvania State University.
    Mack, Holly A.
    Department of Biobehavioral Health, The Pennsylvania State University.
    McClearn, Gerald
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Berg, Stig
    Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Department of Psychology, University of Göteborg.
    Vogler, George P
    Department of Biobehavioral Health, The Pennsylvania State University.
    Stability of Genetic Influences on Pulmonary Function in a Longitudinal Study of Octogenarian Twins2010In: American Journal of Human Biology, ISSN 1042-0533, E-ISSN 1520-6300, Vol. 22, no 3, p. 375-377Article in journal (Refereed)
    Abstract [en]

    Using data from the first four waves of the OCTO-Twin study (twins 80 + years), the present study investigated the stability and change of genetic and environmental contributions to pulmonary function. Using a genetic simplex model, variance in peak expiratory flow (PEF) at each wave was decomposed into additive genetic and nonshared (specific) environmental factors. Additionally, this analysis distinguished the source of these influences, either from previous waves (transmissions) or from novel influences at each wave (innovations). At each time point (except wave 1), the genetic variance was due to genetic transmissions from prior time points. Conversely, the specific environmental variance in PEF at each time point was mainly due to environmental innovations. These results imply that genetic factors contribute to the stability of pulmonary function over time whereas environmental factors contribute to its change.

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