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Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
Division of Medical Diagnostics, Department of Laboratory Medicine, Region Jönköping County, Jönköping, Sweden.
Division of Medical Diagnostics, Department of Laboratory Medicine, Region Jönköping County, Jönköping, Sweden.
Department of Surgery, Region Jönköping County, Jönköping, Sweden.
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2016 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 124, no 9, 736-740 p.Article in journal (Refereed) Published
Abstract [en]

The DNA repair genes XRCC1 and XRCC6 have been proposed to participate in the pathological process of cancer by modulating the DNA repair capacity. This study evaluated the susceptibility of the single-nucleotide polymorphisms (SNPs) XRCC1 (rs25487, G > A) and XRCC6 (rs2267437, C > G) to colorectal cancer (CRC) and their association with clinical parameters in Swedish patients with CRC. Using the TaqMan system, these SNPs were screened in 452 patients and 464 controls. No significant difference in genotype distribution was found between the patients and controls, or any significant association with cancer-specific or disease-free survival in patients. However, we showed that the carriers of allele A in XRCC1 (rs25487, G > A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12–2.41, p = 0.012).

Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 124, no 9, 736-740 p.
Keyword [en]
DNA repair; XRCC1; XRCC6; Single-nucleotide polymorphism; colorectal cancer
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-30846DOI: 10.1111/apm.12563PubMedID: 27328741ScopusID: 2-s2.0-84983401255OAI: oai:DiVA.org:hj-30846DiVA: diva2:942228
Funder
Futurum - Academy for Health and Care, Jönköping County Council, Sweden
Available from: 2016-06-23 Created: 2016-06-23 Last updated: 2016-09-05Bibliographically approved

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