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CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia
Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden, and Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0002-8617-0355
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2016 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 42, 124-131 p.Article in journal (Refereed) Published
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Abstract [en]

The aim of this study was to explore cross-sectional associations between Cardiovascular Risk Factors, Aging and Dementia Study (CAIDE) Dementia Risk Score and dementia-related cerebrospinal fluid and neuroimaging biomarkers in 724 patients without dementia from the Memory Clinic at Karolinska University Hospital, Huddinge, Sweden. We additionally evaluated the score's capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidemia, and hypertension; and one additionally including apolipoprotein E (APOE) ε4 carrier status. Cerebrospinal fluid was analyzed for amyloid β (Aβ), total tau, and phosphorylated tau. Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale, and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher total tau, more severe MTA, WMC, and global cortical atrophy-frontal subscale. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced Aβ, more severe MTA, and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE.

Place, publisher, year, edition, pages
2016. Vol. 42, 124-131 p.
Keyword [en]
Amyloid beta, CAIDE dementia risk score, Mild cognitive impairment, Neurodegeneration, Subjective cognitive impairment, Tau
National Category
Gerontology, specializing in Medical and Health Sciences Geriatrics Neurology
Identifiers
URN: urn:nbn:se:hj:diva-29956DOI: 10.1016/j.neurobiolaging.2016.03.007ISI: 000375129500014PubMedID: 27143429ScopusID: 2-s2.0-84962920586Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-29956DiVA: diva2:929538
Available from: 2016-05-19 Created: 2016-05-19 Last updated: 2017-03-22Bibliographically approved

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