Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association of vitamin B12, folate, and sulfur amino acids with brain magnetic resonance imaging measures in older adults: A longitudinal population-based study
Center for Alzheimer Research–Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden.
Center for Alzheimer Research–Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden, and Department of Neurology, Klinikum Augsburg, Augsburg, Germany.
Center for Alzheimer Research–Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden.
Center for Alzheimer Research–Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden.
Show others and affiliations
2016 (English)In: JAMA psychiatry, ISSN 2168-6238, E-ISSN 2168-622X, Vol. 73, no 6, 606-613 p.Article in journal (Refereed) Published
Abstract [en]

Importance 

Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia.

Objective 

To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume as measured by fluid-attenuated inversion recovery in older adults.

Design, Setting, and Participants 

The magnetic resonance imaging subsample of the Swedish National Study on Aging and Care in Kungsholmen, a population-based longitudinal study in Stockholm, Sweden, was conducted in 501 participants aged 60 years or older who were free of dementia at baseline. A total of 299 participants underwent repeated structural brain magnetic resonance imaging scans from September 17, 2001, to December 17, 2009.

Main Outcomes and Measures 

The rate of brain tissue volume loss and the progression of total white matter hyperintensity volume.

Results 

In the multi-adjusted linear mixed models, among 501 participants (300 women [59.9%]; mean [SD] age, 70.9 [9.1] years), higher baseline vitamin B12 and holotranscobalamin levels were associated with a decreased rate of total brain volume loss during the study period: for each increase of 1 SD, β (SE) was 0.048 (0.013) for vitamin B12 (P < .001) and 0.040 (0.013) for holotranscobalamin (P  = .002). Increased total homocysteine levels were associated with faster rates of total brain volume loss in the whole sample (β [SE] per 1-SD increase, –0.035 [0.015]; P = .02) and with the progression of white matter hyperintensity among participants with systolic blood pressure greater than 140 mm Hg (β [SE] per 1-SD increase, 0.000019 [0.00001]; P = .047). No longitudinal associations were found for red blood cell folate and other sulfur amino acids.

Conclusions and Relevance 

This study suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerated aging of the brain. Randomized clinical trials are needed to determine the importance of vitamin B12 supplementation on slowing brain aging in older adults.

Place, publisher, year, edition, pages
American Medical Association , 2016. Vol. 73, no 6, 606-613 p.
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:hj:diva-29953DOI: 10.1001/jamapsychiatry.2016.0274ISI: 000378868100013PubMedID: 27120188ScopusID: 2-s2.0-84973369462Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-29953DiVA: diva2:929487
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2017-03-21Bibliographically approved

Open Access in DiVA

Fulltext(259 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 259 kBChecksum SHA-512
dfcb3c6917505c4ddd0496368ca947b193081ae04c296eb089ae5e71fbbd66d07da1dd0d429dedbe9f6753c945c66487f36c83f09f74a579e19c96eb602958a4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Kåreholt, Ingemar
By organisation
HHJ, Institute of GerontologyHHJ. ARN-J (Aging Research Network - Jönköping)
In the same journal
JAMA psychiatry
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 70 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf