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Influence of fibrillin-1 genotype on the aortic stiffness in men
University Hospitals of Coventry and Warwickshire, Walsgrave, Coventry, United Kingdom.
University Hospitals of Coventry and Warwickshire, Walsgrave, Coventry, United Kingdom.
University Hospitals of Coventry and Warwickshire, Walsgrave, Coventry, United Kingdom.
Division of Clinical Physiology, Department of Medicine and Care, University Hospital, Linköping, Sweden.
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2005 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 99, no 3, 1036-1040 p.Article in journal (Refereed) PublishedText
Abstract [en]

Aortic stiffness is a, predictor of cardiovascular mortality. The mechanical properties of the arterial wall depend on the connective tissue framework, with variation in fibrillin-1 and collagen I genes being associated with aortic stiffness and/or pulse pressure elevation. The aim of this study was to investigate whether variation in fibrillin-1 genotype was associated with aortic stiffness in men. The mechanical properties 4 the abdominal aorta of 79 healthy pen (range 28-81 yr) were investigated by ultrasonographic phase-locked echo tracking. Fibrillin-1 genotype, characterized by the variable tandem repeat in intron 28, and collagen type I alpha I genotype characterized by the 2,064 G>T polymorphism, were deterimined by using DNA from peripheral blood cells. Three common fibrillin-1 genotypes, 2-2, 2-3, and 2-4, were observed in 50 (64%), 10 (13%), and 11 (14%) of the men, respectively. Those of 2-3 genotype had higher pressure strain elastic modulus and aortic stiffness compared with men of 2-2 or 2-4 genotype (P = 0.005). Pulse pressure also was increased in the 2-3 genotype (P = 0.04). There was no significant association between type I collagen genotype and aortic stiffness in this cohort. In conclusion, the fibrillin-1 2-3 genotype in men was associated with increased aortic stiffness and pulse pressure, indicative of an increased risk for cardiovascular disease.

Place, publisher, year, edition, pages
2005. Vol. 99, no 3, 1036-1040 p.
Keyword [en]
blood pressure, collagen, elastin, mechanics
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:hj:diva-29487DOI: 10.1152/japplphysiol.00554.2004ISI: 000231538000036PubMedID: 16103519ScopusID: 2-s2.0-24044526512OAI: oai:DiVA.org:hj-29487DiVA: diva2:905627
Available from: 2016-02-23 Created: 2016-02-23 Last updated: 2016-02-23Bibliographically approved

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