Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Non-verbal and verbal fluency in prodromal Huntington’s disease
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm; School of Medicine, University of Queensland, Brisbane, Qld.
School of Psychology, Flinders University, Adelaide, S.A., Australia.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.ORCID iD: 0000-0002-8212-823X
School of Medicine, University of Queensland, Brisbane, Qld.
2015 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 5, no 3, 517-529 p.Article in journal (Refereed) Published
Abstract [en]

Background: This study examines nonverbal (design) and verbal (phonemic and semantic) fluency in prodromal Huntington’s disease (HD). An accumulating body of research indicates subtle deficits in cognitive functioning among prodromal mutation carriers for HD. Methods: Performance was compared between 32 mutation carriers and 38 noncarriers in order to examine the magnitude of impairment across fluency tasks. The Predicted Years To Onset (PYTO) in mutation carriers was calculated by a regression equation and used to divide the group according to whether onset was predicted less than 12.75 years (HD+CLOSE; n=16) or greater than 12.75 years (HD+DISTANT; n=16). Results: The results indicate that both nonverbal and verbal fluency are sensitive to subtle impairment in prodromal HD. HD+CLOSE group produced fewer items in all assessed fluency tasks compared to noncarriers. HD+DISTANT produced fewer drawings than noncarriers in the nonverbal task. PYTO correlated significantly with all measures of nonverbal and verbal fluency. Conclusion: The pattern of results indicates that subtle cognitive deficits exist in prodromal HD, and that less structured tasks with high executive demands are the most sensitive in detecting divergence from the normal range of functioning. These selective impairments can be attributed to the early involvement of frontostriatal circuitry and frontal lobes.

Place, publisher, year, edition, pages
2015. Vol. 5, no 3, 517-529 p.
Keyword [en]
Prodromal, cognition, neuropsychology, nonverbal fluency, phonemic fluency, semantic fluency, executive functioning
National Category
Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-28648DOI: 10.1159/000441942ISI: 000367324900024PubMedID: 26955384Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-28648DiVA: diva2:882798
Available from: 2015-12-15 Created: 2015-12-15 Last updated: 2016-03-24Bibliographically approved

Open Access in DiVA

fulltext(1603 kB)36 downloads
File information
File name FULLTEXT01.pdfFile size 1603 kBChecksum SHA-512
c8baa9301355a1a777a0921b37c2e82823fdc3885296ecd6df1d6e7f2682e3353d8ffcd476dc11ec679554cb9d125640f3eff4f50bdabf7bf67bf534bb90a8fd
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wahlin, Åke
By organisation
HHJ, Institute of GerontologyHHJ. Ageing - living conditions and health
In the same journal
Dementia and geriatric cognitive disorders extra
Gerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 36 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 113 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf