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Episodic Learning and Memory in Prodromal Huntington’s Disease: The Role of Multimodal Encoding and Selective Reminding
Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden; School of Medicine, The University of Queensland, Brisbane, Australia.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.ORCID iD: 0000-0002-8212-823x
School of Medicine, The University of Queensland, Brisbane, Australia.
2015 (English)In: International Journal of Clinical Medicine, ISSN 2158-284X, E-ISSN 2158-2882, Vol. 6, no 11, p. 876-886Article in journal (Refereed) Published
Abstract [en]

This study investigated episodic memory in prodromal HD. Three groups were compared (N=70): mutation carriers with less than 12.5 years to disease onset (n=16), mutation carriers with 12.5 or more years to disease onset (n=16), and noncarriers (n=38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which includes multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which includes verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.

Place, publisher, year, edition, pages
2015. Vol. 6, no 11, p. 876-886
Keywords [en]
Prodromal Huntington’s disease, Fuld Object Memory Evaluation, Episodic Memory, Short-Term Memory, Neurodegenerative Diseases
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-28646DOI: 10.4236/ijcm.2015.611115Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-28646DiVA, id: diva2:882791
Available from: 2015-12-15 Created: 2015-12-15 Last updated: 2022-03-17

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Wahlin, Åke

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