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Impaired Abdominal aortic wall Integrity in Elderly Men Carrying the Angiotensin-converting Enzyme D Allele
Linköping University.
Linköping University.
Linköping University.
Linköping University.
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2011 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 42, no 3, 309-316 p.Article in journal (Refereed) Published
Abstract [en]

Objective: A polymorphism in the angiotensin-converting-enzyme gene (ACE I/D) has been associated with abdominal aortic aneurysm and a link between aortic aneurysm and aortic stiffness has been suggested. This study aimed to explore the links between ACE I/D polymorphism, circulating ACE and abdominal aortic wall integrity as reflected by abdominal aortic wall stiffness.

Material: A total of 212 men and 194 women, aged 70-88 years, were studied. Methods: Mechanical properties of the abdominal aorta were determined using the Wall Track System, ACE genotype using the polymerase chain reaction (PCR) and circulating ACE level by enzyme-linked immunosorbent assay (ELISA).

Results: In men, pulsatile diameter change differed between genotypes (II 0.70, ID 0.55 and DD 0.60 mm, P = 0.048), whereas a tendency was seen for distensibility coefficient (DC) (II 10.38, ID 7.68 and ID 8.79, P = 0.058). Using a dominant model (II vs. ID/DD), men carrying the ACE D allele had lower pulsatile diameter change (P = 0.014) and DC (P = 0.017) than II carriers. Multiple regression analyses showed additional associations between the D allele and increased stiffness beta, and reduced compliance coefficient.

Conclusion: Men carrying the ACE D allele have stiffer abdominal aortas compared with II carriers. Deranged abdominal aortic stiffness indicates impaired vessel wall integrity, which, along with other local predisposing factors, may be important in aneurysmal disease. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2011. Vol. 42, no 3, 309-316 p.
Keyword [en]
Arterial stiffness, Distensibility, Gene polymorphism, Mechanical properties, Aorta
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:hj:diva-28379DOI: 10.1016/j.ejvs.2011.04.010ISI: 000295061800007PubMedID: 21570325OAI: oai:DiVA.org:hj-28379DiVA: diva2:873873
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2015-11-25Bibliographically approved

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CiteExportLink to record
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