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Neuroprotection in HIV-positive drug users: Implications for antioxidant therapy
University of Miami School of Medicine, Division of Disease Prevention, Department of Psychiatry and Behavioral Sciences, Miami, FL, United States.
Department of Psychiatry and Behavioral Sciences, Division of Disease Prevention, University of Miami School of Medicine, Miami, FL, United States.
Department of Psychiatry and Behavioral Sciences, Division of Disease Prevention, University of Miami School of Medicine, Miami, FL, United States.
Department of Psychiatry and Behavioral Sciences, Division of Disease Prevention, University of Miami School of Medicine, Miami, FL, United States.
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2002 (English)In: Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, E-ISSN 1944-7884, Vol. 31, S84-S88 p.Article in journal (Refereed) Published
Abstract [en]

Impaired neuroprotection resulting from oxidative stress has been implicated in neurodegeneration in a number of pathologic conditions of the brain, including both subcortical and cortical type dementias. Production of excessive oxidative stress, moreover, can lead to elevated levels of certain proinflammatory cytokines that are considered to be contributing factors to neuronal injury and are evident in HIV-related dementia as well as in other neurodegenerative conditions. Inhibitors of oxidative damage could thus be promising therapeutic agents for preventing progressive nerve cell death and slowing the advance of neurodegenerative disease. The potential of antioxidant therapy to provide neuroprotection is substantiated by studies demonstrating reduced oxidative stress with supplementation and lower risk for cognitive impairment with higher plasma antioxidant levels.

Place, publisher, year, edition, pages
2002. Vol. 31, S84-S88 p.
Keyword [en]
neuroprotection, oxidative stress, antioxidants, HIV/AIDS
National Category
Immunology
Identifiers
URN: urn:nbn:se:hj:diva-27957DOI: 10.1097/01.QAI.0000028069.79472.6FISI: 000179080000009PubMedID: 12394787Scopus ID: 2-s2.0-0036797380OAI: oai:DiVA.org:hj-27957DiVA: diva2:854429
Conference
Workshop on Metabolic Disorders in the Pathogenesis of Nervous System Damage in HIV-Infected Drug Abusers, SEP 28-29, 1999, BETHESDA, MARYLAND
Available from: 2015-09-16 Created: 2015-09-16 Last updated: 2015-09-16Bibliographically approved

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