Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Impact of selenium status on the pathogenesis of mycobacterial disease in HIV-1-infected drug users during the era of highly active antiretroviral therapy
Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States.
Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States.
Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States.
Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States.
Show others and affiliations
2002 (English)In: Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, E-ISSN 1944-7884, Vol. 29, no 2, 169-173 p.Article in journal (Refereed) Published
Abstract [en]

The risk of mycobacterial disease is significantly increased in drug abusers as well as in immunocompromised HIV-1-infected individuals. The essential trace element selenium has an important function in maintaining immune processes and may, thus, have a critical role in clearance of mycobacteria. The impact of selenium status on the development of mycobacterial diseases in HIV-1-seropositive drug users was investigated over a 2-year period (1999-2001). Twelve cases of mycobacterial disease (tuberculosis, 9; infection due to atypical Mycobacterium species, 3) occurred; these 12 cases were compared with 32 controls with no history of respiratory infections who were matched on age, sex, and HIV status. Significant risk for development of mycobacterial disease was associated with a CD4 cell count of <200/mm(3), malnutrition, and selenium levels of less than or equal to 135 mug/L (patients with these levels were 13 times more likely to develop mycobacterial disease). Multivariate analyses controlling for antiretroviral treatment and CD4 cell count revealed that both body mass index and selenium level remained significant factors in the relative risk for developing mycobacterial disease (relative risk, 3; p =.015); these findings suggest that selenium status may have a profound impact on the pathogenesis of mycobacterial disease.

Place, publisher, year, edition, pages
2002. Vol. 29, no 2, 169-173 p.
Keyword [en]
tuberculosis, selenium, malnutrition, drug users, HIV/AIDS
National Category
Immunology
Identifiers
URN: urn:nbn:se:hj:diva-27958ISI: 000173890200010PubMedID: 11832687Scopus ID: 2-s2.0-0036470988OAI: oai:DiVA.org:hj-27958DiVA: diva2:854419
Available from: 2015-09-16 Created: 2015-09-16 Last updated: 2015-09-16Bibliographically approved

Open Access in DiVA

No full text

PubMedScopus

Search in DiVA

By author/editor
Lecusay, Robert
In the same journal
Journal of Acquired Immune Deficiency Syndromes
Immunology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 115 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf