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Perforin, CD28 and CD95 expression in circulating CD4 and CD8 cells as predictors of head and neck (H&N) cancer patient survival
Department of Laboratory Medicine, Ryhov Hospital, SE-55185, Jönköping, Sweden.
Department of ENT, Ryhov Hospital, Jönköping, Sweden.
Department of ENT, Karolinska University Hospital, Stockholm, Sweden.
Swedish Match AB, Stockholm, Sweden.
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2014 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 31, no 12, p. 290-Article in journal (Refereed) Published
Abstract [en]

Long-term survival of H&N cancer patients has not improved significantly over the last 30 years. The possibility of using circulating blood cell phenotypes as a prognostic biomarker of H&N cancer patient was investigated in this study. Pre-treatment, circulating T lymphocyte subpopulations as well as the survival time of the patients in question were studied. Upregulated CD4+ perforin+ and CD8+ CD95+ but downregulated CD4+ CD28+ (p < 0.001) were detected in H&N cancer patients. With 3 years of follow-up time, an increase in the frequency of the pre-treatment, circulating CD4+ perforin+ cells and CD8+ perforin+ cells was showed to have reverse effects on the survival time in H&N cancer patients (p < 0.01). Detection of perforin? frequency in CD4+ and CD8+ lymphocyte by FACS is fast, simple and cost-effective. A potential role of perforin expression in CD4+ and CD8+ cells as a prognostic biomarker for H&N cancer patient in the clinical setting was suggested.

Place, publisher, year, edition, pages
2014. Vol. 31, no 12, p. 290-
Keywords [en]
Perforin, CD28, CD95, Circulating T cells, Survival time H&N cancer patients
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-25896DOI: 10.1007/s12032-014-0290-3ISI: 000344531800009PubMedID: 25344268Scopus ID: 2-s2.0-84932140033OAI: oai:DiVA.org:hj-25896DiVA, id: diva2:789225
Available from: 2015-02-18 Created: 2015-02-18 Last updated: 2017-12-04Bibliographically approved

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CiteExportLink to record
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