The purpose of this paper is to identify if and how supply chain practices are linked to moral disengagement techniques and thus might cause moral decoupling (MD). The research uses a literature review and multiple case study approach to investigate this issue. The literature review links moral disengagement to supply chain practices, while the case study observes the existence of the practices, and in what supply chain configurations those practices might arise. Identified configurations that might cause MD are suppliers and external partners responsible for upstream activities, division of tasks, aggregation of materials, auction-like settings, long supply chains, production in low-cost countries, production where people are not considered as equals, and configurations made to reduce costs.