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Association between EEG Abnormalities and CSF Biomarkers in a Memory Clinic Cohort
University Medical Centre Ljubljana.
Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
Karolinska University Hospital Huddinge.
Karolinska Institutet.
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2013 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 36, no 5-6, 319-328 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers. Methods: Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). Results: BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). Conclusions: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.

Place, publisher, year, edition, pages
2013. Vol. 36, no 5-6, 319-328 p.
Keyword [en]
Electroencephalography, Cerebrospinal fluic, Biomarkers Alzheimer´s disease Mild cognitive impariment
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:hj:diva-23097DOI: 10.1159/000351677Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-23097DiVA: diva2:687506
Available from: 2014-01-14 Created: 2014-01-14 Last updated: 2015-11-25Bibliographically approved

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