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Synergy effects of HbA(1c) and variants of APOE and BDNFVal(66)Met explains individual differences in memory performance
Karolinska Institutet.
Karolinska Institutet.
Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.ORCID iD: 0000-0002-8212-823X
2013 (English)In: Neurobiology of Learning and Memory, ISSN 1074-7427, E-ISSN 1095-9564, Vol. 106, 274-282 p.Article in journal (Refereed) Published
Abstract [en]

We aimed at exploring if synergy effects of Brain-Derived Neurotrophic Factor (BDNF) Val66Met, Apolipoprotein E (APOE) and HbA1c (glycated haemoglobin) could explain individual differences in memory performance over 10 years in a population based sample of nondemented adults (N = 888, 35–85 years at baseline). Episodic memory was affected by such agents, wheras semantic memory was spared. Both age and HbA1c were associated with episodic memory decline. BDNF66Met carriers with higher HbA1c levels evidenced slope decline in episodic recall. We found support for joint effects of BDNFVal66Met × APOE × HbA1c and BDNFVal66Met × APOE × age on rates of episodic memory change over ten years, after controlling for age, sex, education and cardiovascular diseases. We conclude that variants of genetic polymorphisms act in synergy with long-term blood glucose control in shaping patterns of cognitive aging.

Place, publisher, year, edition, pages
2013. Vol. 106, 274-282 p.
Keyword [en]
Aging, Episodic memory, BDNF, APOE, Hba1c Epistatis
National Category
Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-23083DOI: 10.1016/j.nlm.2013.08.017OAI: oai:DiVA.org:hj-23083DiVA: diva2:687311
Available from: 2014-01-14 Created: 2014-01-14 Last updated: 2015-01-14Bibliographically approved

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Wahlin, Åke
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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More styles
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