Cyber-physical networks open new possibilities to supply chain configuration. They are based on Cyber-Physical Systems (CPS), which tightly integrate physical systems and cyber (IT) systems based on interaction between these systems in real time. Operation and configuration of CPS require approaches for managing the variability at design time and the dynamics at runtime caused by a multitude of component types and changing application environments. The proposed approach benefits from integration of such technologies as multilevel self-organisation and knowledge fusion. Self-organisation within cyber-physical networks opens the avenue towards providing new services at runtime, which need to be accommodated in the business models. Adaptable business models are a promising approach to this challenge.