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Sleep disordered breathing in community dwelling elderly: Associations with cardiovascular disease, impaired systolic function, and mortality after a six-year follow-up
Linköping University.
Linköping University.
Linköping University.
Linköping University.
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2011 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 12, no 8, 748-53 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Sleep disordered breathing (SDB), cardiovascular disease (CVD) and impaired cardiac function are common in elderly people. We investigated the association of SDB and mortality in a community dwelling elderly population, considering CVD and objectively measured impaired cardiac function have been poorly studied thus far.

AIM: To investigate whether SDB is a factor that affects mortality in elderly people, with a focus on those with CVD and/or signs of impaired cardiac function.

METHODS: A prospective cohort design was used and 331 community dwelling elderly aged 71-87 years underwent one-night polygraphic recordings in the subjects' homes. CVD and systolic function were objectively established. Mortality data were collected after 6 years.

RESULTS: In the total population there were no significant associations between mortality and SDB. In those with CVD and impaired systolic function, as measured by NT-proBNP, oxygen desaturation index (ODI) ≥10 was associated with mortality. The hazard ratio of 3.0 (CI 95% 1.1-8.6, p=0.03) remained statistically significant after adjustments for age, gender, diabetes and plasma values of NT-proBNP.

CONCLUSION: SDB in community dwelling elderly has no overall association to mortality irrespective of degree of SDB. However, hypoxic events (i.e., ODI ≥10) were associated with mortality in the group who had CVD in combination with impaired systolic function.

Place, publisher, year, edition, pages
2011. Vol. 12, no 8, 748-53 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-20367DOI: 10.1016/j.sleep.2011.03.012PubMedID: 21724460OAI: oai:DiVA.org:hj-20367DiVA: diva2:599935
Available from: 2013-01-22 Created: 2013-01-22 Last updated: 2013-07-30Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
  • vancouver
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More styles
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