Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sortilin receptor 1 predicts longitudinal cognitive change
Department of Psychology, University of California, Riverside, CA, USA.
Department of Psychology, University of California, Riverside, CA, USA.
Department of Psychology, University of Southern California, USA.
Department of Psychology, University of California, Riverside, CA, USA.
Show others and affiliations
2013 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 34, no 6, 1710.e11-1710.e18 p.Article in journal (Refereed) Published
Abstract [en]

The gene encoding sortilin receptor 1 (SORL1) has been associated with Alzheimer's disease risk. We examined 15 SORL1 variants and single nucleotide polymorphism (SNP) set risk scores in relation to longitudinal verbal, spatial, memory, and perceptual speed performance, testing for age trends and sex-specific effects. Altogether, 1609 individuals from 3 population-based Swedish twin studies were assessed up to 5 times across 16 years. Controlling for apolipoprotein E genotype (APOE), multiple simple and sex-moderated associations were observed for spatial, episodic memory, and verbal trajectories (p = 1.25E-03 to p = 4.83E-02). Five variants (rs11600875, rs753780, rs7105365, rs11820794, rs2070045) were associated across domains. Notably, in those homozygous for the rs2070045 risk allele, men demonstrated initially favorable performance but accelerating declines, and women showed overall lower performance. SNP set risk scores predicted spatial (Card Rotations, p = 5.92E-03) and episodic memory trajectories (Thurstone Picture Memory, p = 3.34E-02), where higher risk scores benefited men's versus women's performance up to age 75 but with accelerating declines. SORL1 is associated with cognitive aging, and might contribute differentially to change in men and women.

Place, publisher, year, edition, pages
2013. Vol. 34, no 6, 1710.e11-1710.e18 p.
Keyword [en]
Cognitive decline, SORL1 association, Sortilin receptor 1, SNP set risk scores, Sex differences, Aging
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-20362DOI: 10.1016/j.neurobiolaging.2012.12.006Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-20362DiVA: diva2:599913
Available from: 2013-01-22 Created: 2013-01-22 Last updated: 2014-03-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Malmberg, Bo
By organisation
HHJ, Institute of GerontologyHHJ. Ageing - living conditions and health
In the same journal
Neurobiology of Aging
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 242 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf