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A 5-year prospective population-based study of juvenile chronic arthritis: onset, disease process, and outcome
Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden.
Jönköping University, School of Health Science, HHJ, Quality Improvement and Leadership in Health and Welfare. Jönköping University, The Jönköping Academy for Improvement of Health and Welfare.
Department of Paediatrics, University of Gothenburg, Sweden.
Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden.
2012 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 41, no 5, 379-82 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate, in a population-based cohort of patients with juvenile chronic arthritis (JCA), onset characteristics, progression, outcome, and prognostic factors longitudinally for 5 years. Methods: This cohort consisted of 132 incidence cases identified between 1984 and 1986 in southwestern Sweden followed for 5 years with annual reports of subgroup, joint assessment, disease activity, eye examinations, laboratory measurements, and medication. At the 5-year follow-up, the Childhood Health Assessment Questionnaire (Child-HAQ) was evaluated. European League Against Rheumatism (EULAR) criteria for diagnosis and disease activity were used. Results: During the 5 years only four patients were lost to follow-up, 34% changed subgroup and 8% developed uveitis. At the 5-year follow-up the disease was active in 12% of the patients, stable in 28%, inactive in 25%, and in remission in 34%. Among those examined, 24% had radiological changes, of whom half had advanced changes. The Child-HAQ median score at the 5-year follow-up was 0.13 (range 0.0-1.9). The number of involved joints at inclusion correlated positively with active disease at the 5-year follow-up. Age at disease onset, the number of involved joints, and the number of joints with arthritis correlated positively with continuous disease and Child-HAQ score. Conclusion. Our study shows a diverse disease course during the first 5 years of JCA where one-third changed subgroup and two-thirds did not reach remission. Age of disease onset, the number of involved joints, and the number of joints with arthritis at inclusion were associated with poor outcome at the 5-year follow-up.

Place, publisher, year, edition, pages
2012. Vol. 41, no 5, 379-82 p.
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hj:diva-19963DOI: 10.3109/03009742.2012.677472ISBN: 1502-7732 (Electronic) 0300-9742 (Linking) OAI: oai:DiVA.org:hj-19963DiVA: diva2:574046
Available from: 2012-12-04 Created: 2012-11-30 Last updated: 2012-12-04Bibliographically approved

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