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Cerebrospinal fluid alzheimer markers in depressed elderly dubjects with and without alzheimer's disease
Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
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2012 (English)In: Dementia and Geriatric Cognitive Disorders. Extra., ISSN 1664-5464, Vol. 2, no 1, 48-56 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this study was to explore the relationship between cerebrospinal fluid Alzheimer's disease (AD) markers and depression in elderly people.

Method: We included subjects with AD as well as persons with subjective cognitive impairment and normal cognition. Depression was assessed with the Cornell Scale for Depression in Dementia, and a cut-off score of >6 was used to define depression. Cerebrospinal fluid was analyzed using commercially available assays for β-amyloid 1-42, total tau, and phosphorylated tau 181.

Result: A total of 183 participants (66.7% female) were included (92 with AD and 91 with subjective cognitive impairment), with a mean age (±SD) of 67.6 ± 7.4 years, a Mini-Mental State Examination score of 26.0 ± 4.0, and a median Cornell Scale for Depression in Dementia score of 5 (range 0-19). Depression scores were not associated with higher phosphorylated tau 181 and total tau or reduced β-amyloid 1-42 in AD or non-demented subjects.

Conclusions: These results suggest that AD pathology does not contribute to depression, indicating that other factors may be more important. Further studies of the aetiology of depression in elderly people with and without AD are warranted.

Place, publisher, year, edition, pages
2012. Vol. 2, no 1, 48-56 p.
Keyword [en]
alzheimer's disease, cerebrospinal fluid, depression, elderly, phosphorylated tau, total tau, β-Amyloid 1–24
National Category
Public Health, Global Health, Social Medicine and Epidemiology Neurosciences Neurology
Identifiers
URN: urn:nbn:se:hj:diva-19907DOI: 10.1159/000334644PubMedID: 22649429OAI: oai:DiVA.org:hj-19907DiVA: diva2:572564
Available from: 2012-11-28 Created: 2012-11-28 Last updated: 2014-03-11Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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  • asciidoc
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