The results of the paper are derived from a longitudinal case study of a single product development project faced with high degrees of uncertainty and equivocality. The findings reveal that national and cultural difference between project team members affect the R&D-manufacturing interface as creating communication challenges. In this paper three communication challenges within the R&D-manufacturing interface in context of geographical distance were outlined: 1) clarity of transferred information; 2) intention to transfer information; 3) responsiveness to information received. Further, the study indicates that high degree of equivocality in the context of cultural and language differences can be handled not only by the use of rich communication media, but also by employing less-rich communication media such as e-mail, or “picture books”.