This paper empirically illustrates how interactive research can serve as a platform for adopting systems thinking in workplace design within the Mail Service Division of the Swedish Post Office and thereby contributing to efficient and healthy work processes for postmen in mail distribution. The interactive approach has made it possible to illuminate collaboration between researchers and practitioners in a down-to-earth and realistic manner during a five-year period. The results show how an interactive approach can promote a systems perspective and the opportunities to obtain clarity with regard to which factors influence efficiency in a production system as a whole and how to transform this knowledge into practical solutions.