Post-industrial economic restructuring in developed countries has downgraded the role of blue-collar labour in regional growth, giving way, conversely, to occupations that demand high concentrations of human capital. Human capital has been documented to positively affect regional growth and income, signifying an urban planning shift towards amenities provision, as a human capital attraction tool. An emerging, highly-valued amenity in the post-industrial society is nightlife. Following Florida’s reasoning on the rising salience of the creative class, this paper investigates the hypothesis that nightlife attracts high human capital or skilled individuals. It focuses on the paradigm of Greece, using data acquired by the Greek statistics agency and, to a lesser extent, the Greek yellow pages. It employs two measures, the human capital one –calculated as the percentage of the population holding a bachelor degree and above- and an approximation of Florida’s creative class measure –occupational categorization according to job complexity. Bivariate correlations are applied to account for human capital attracting factors and structural equation modelling to assess nightlife’s impact on the two measures and respectively, on regional growth.