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Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter -420C>G genotype.
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2008 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, no 10, p. 1008-1014Article in journal (Refereed) Published
Abstract [en]

A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.

Place, publisher, year, edition, pages
Taylor & Francis, 2008. Vol. 26, no 10, p. 1008-1014
Keywords [en]
Resistin; Protein expression; Colorectal cancer; Polymorphism
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-5969DOI: 10.1080/07357900802087267ISI: 000261802800008PubMedID: 18798067Scopus ID: 2-s2.0-57749192711OAI: oai:DiVA.org:hj-5969DiVA, id: diva2:36789
Available from: 2008-11-13 Created: 2008-11-13 Last updated: 2019-12-20Bibliographically approved

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Dimberg, Jan

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