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Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.
Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
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2006 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 176, no 4, p. 2645-2653Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 176, no 4, p. 2645-2653
Keywords [en]
Aged; 80 and over, Aging/*immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/cytology/*immunology/*pathology, Clone Cells/cytology/immunology, Cytomegalovirus/*immunology, Cytomegalovirus Infections/*immunology/*mortality/virology, Female, Humans, Interferon Type II/secretion, Longitudinal Studies, Male, Phenotype, Receptors; Antigen; T-Cell/immunology
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URN: urn:nbn:se:hj:diva-4282PubMedID: 16456027OAI: oai:DiVA.org:hj-4282DiVA, id: diva2:35102
Available from: 2007-10-31 Created: 2007-10-31 Last updated: 2017-12-12Bibliographically approved

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Strindhall, JanWikby, Anders

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