The oral cavity is lined with epithelium derived from the ectoderm. The development of structures derived from this cell layer is similar to the development of extra-oral structures derived from epithelium. Tooth development is extensively studied in mammals and represents a common pattern for the development of ectodermal placodes deployed in diverse types of epithelium organogenesis, such as salivary glands, mammary glands, sweat glands, limb buds, and more [1].