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Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden; Brain and Mind Institute, The Aga Khan University, Nairobi, Kenya; Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC, United States.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
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2024 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 20, no 7, p. 4486-4498Article in journal (Refereed) Published
Sustainable development
00. Sustainable Development, 3. Good health and well-being
Abstract [en]

INTRODUCTION: Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.

METHODS: We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3-year follow-up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol.

RESULTS: Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial association of CRI on cognition. A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio. No association was found between CRI and AD-related biomarkers.

DISCUSSION: Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients. Highlights: Physiological stress may reduce the neurocognitive benefits accrued from cognitively stimulating and enriching life experiences (cognitive reserve [CR]) in memory clinic patients. Cortisol awakening response modified the relation between CR and P-tau181, a marker of Alzheimer's disease (AD). Effective stress management techniques for AD and related dementia prevention are warranted.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024. Vol. 20, no 7, p. 4486-4498
Keywords [en]
amyloid beta, cerebrospinal fluid biomarkers, cognitive performance, cognitive reserve, memory clinic, perceived stress, phosphorylated tau, salivary cortisol, total tau
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hj:diva-64784DOI: 10.1002/alz.13866ISI: 001239197700001PubMedID: 38837661Scopus ID: 2-s2.0-85195143468Local ID: HOA;intsam;955357OAI: oai:DiVA.org:hj-64784DiVA, id: diva2:1867290
Funder
Swedish Research CouncilAlzheimerfondenThe Swedish Brain FoundationKnut and Alice Wallenberg FoundationForte, Swedish Research Council for Health, Working Life and WelfareKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseRiksbankens JubileumsfondNordForskEU, European Research CouncilAvailable from: 2024-06-10 Created: 2024-06-10 Last updated: 2024-07-19Bibliographically approved

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