Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic studyShow others and affiliations
2024 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 20, no 7, p. 4486-4498Article in journal (Refereed) Published
Sustainable development
00. Sustainable Development, 3. Good health and well-being
Abstract [en]
INTRODUCTION: Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.
METHODS: We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3-year follow-up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol.
RESULTS: Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial association of CRI on cognition. A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio. No association was found between CRI and AD-related biomarkers.
DISCUSSION: Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients. Highlights: Physiological stress may reduce the neurocognitive benefits accrued from cognitively stimulating and enriching life experiences (cognitive reserve [CR]) in memory clinic patients. Cortisol awakening response modified the relation between CR and P-tau181, a marker of Alzheimer's disease (AD). Effective stress management techniques for AD and related dementia prevention are warranted.
Place, publisher, year, edition, pages
John Wiley & Sons, 2024. Vol. 20, no 7, p. 4486-4498
Keywords [en]
amyloid beta, cerebrospinal fluid biomarkers, cognitive performance, cognitive reserve, memory clinic, perceived stress, phosphorylated tau, salivary cortisol, total tau
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hj:diva-64784DOI: 10.1002/alz.13866ISI: 001239197700001PubMedID: 38837661Scopus ID: 2-s2.0-85195143468Local ID: HOA;intsam;955357OAI: oai:DiVA.org:hj-64784DiVA, id: diva2:1867290
Funder
Swedish Research CouncilAlzheimerfondenThe Swedish Brain FoundationKnut and Alice Wallenberg FoundationForte, Swedish Research Council for Health, Working Life and WelfareKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseRiksbankens JubileumsfondNordForskEU, European Research Council2024-06-102024-06-102024-07-19Bibliographically approved