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Mutational meltdown in asexual populations doomed to extinction
Jönköping University, School of Engineering, JTH, Physics and Mathematics and Chemical Engineering. Department of Mathematics, Trinity University, San Antonio, TX, United States.ORCID iD: 0000-0002-4528-5658
Department of Biology and Biochemistry, University of Houston, Houston, TX, United States.
Department of Mathematics, Trinity University, San Antonio, TX, United States.
Department of Biology and Biochemistry, University of Houston, Houston, TX, United States.
2023 (English)In: Journal of Mathematical Biology, ISSN 0303-6812, E-ISSN 1432-1416, Vol. 87, no 6, article id 88Article in journal (Refereed) Published
Abstract [en]

Asexual populations are expected to accumulate deleterious mutations through a process known as Muller’s ratchet. Lynch and colleagues proposed that the ratchet eventually results in a vicious cycle of mutation accumulation and population decline that drives populations to extinction. They called this phenomenon mutational meltdown. Here, we analyze mutational meltdown using a multi-type branching process model where, in the presence of mutation, populations are doomed to extinction. We analyse the change in size and composition of the population and the time of extinction under this model.

Place, publisher, year, edition, pages
Springer, 2023. Vol. 87, no 6, article id 88
Keywords [en]
Branching processes, Evolutionary rescue, Extinction, Lethal mutagenesis, Muller’s ratchet, Mutational meltdown, article, human, mutation accumulation
National Category
Mathematics Evolutionary Biology
Identifiers
URN: urn:nbn:se:hj:diva-62993DOI: 10.1007/s00285-023-02019-yISI: 001106705100001PubMedID: 37994999Scopus ID: 2-s2.0-85177680595Local ID: ;intsam;1816909OAI: oai:DiVA.org:hj-62993DiVA, id: diva2:1816909
Funder
NIH (National Institutes of Health), R01GM101352, R15GM093957Available from: 2023-12-04 Created: 2023-12-04 Last updated: 2023-12-12Bibliographically approved

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Olofsson, Peter

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