Practitioners in the traditional construction have successfully been using generative design for optimization of building projects, however there is limited knowledge on these applications in industrialized house building. This study therefore identifies the current level of digitalization, BIM interoperability and platform flexibility as prerequisites for generative design applications in a case study. The level of digitalization and BIM interoperability are currently not at a high enough level to support the full use of generative design. However, platform flexibility for single-family housing built in panelized elements and multi-family housing built in volumetric elements can enable use of generative design applications.