Epilepsy, like many common medical disorders, can cause sexual dysfunction. However, the prevalence and nature of sexual dysfunction among people with epilepsy, its causes, and optimal management strategies are unclear. Sexual dysfunction in epilepsy is caused by several factors including disease-related factors and drug treatment, psychiatric factors, and social factors. Due to the significant prevalence of sexual dysfunction among patients with epilepsy, the synergistic effect of sexual dysfunction, and mental disorders, design and implementation of psychological interventions including mindfulness-based cognitive therapy (MBCT) for sexual disorders among patients with epilepsy have been proposed. MBCT is an approach to psychotherapy that uses cognitive-behavioral therapy (CBT) techniques alongside mindfulness meditation techniques. MBCT protocol has been adapted to treat female sexual dysfunction of different groups including epilepsy showing promising effects. Consequently, issues concerning sexual activity should be raised by healthcare professionals as a routine part of the management of patients with epilepsy, and MBCT can be considered as a promising effective treatment strategy.