Occupational complexity and cognition in the FINGER multidomain intervention trialDepartment of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Neurocenter/Neurology, Kuopio University Hospital, Kuopio, Finland.
Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Work Ability and Working Careers, Finnish Institute of Occupational Health, Helsinki, Finland.
Department of Welfare; Ageing, Disability and Functioning Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Department of Social and, Psychological Sciences, Karlstad University, Karlstad, Sweden.
Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Show others and affiliations
2022 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 18, no 12, p. 2438-2447Article in journal (Refereed) Published
Sustainable development
3. Good health and well-being
Abstract [en]
Introduction: Lifetime exposure to occupational complexity is linked to late-life cognition, and may affect benefits of preventive interventions.
Methods: In the 2-year multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated, through post hoc analyses (N = 1026), the association of occupational complexity with cognition. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles.
Results: Higher levels of occupational complexity were associated with better baseline cognition. Measures of occupational complexity had no association with intervention effects on cognition, except for occupational complexity with data, which was associated with the degree of intervention-related gains for executive function.
Discussion: In older adults at increased risk for dementia, higher occupational complexity is associated with better cognition. The cognitive benefit of the FINGER intervention did not vary significantly among participants with different levels of occupational complexity. These exploratory findings require further testing in larger studies.
Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 18, no 12, p. 2438-2447
Keywords [en]
Alzheimer's disease, cognitive decline, cognitive reserve, dementia, intelligence, multidomain intervention, occupational complexity, prevention, randomized controlled trials
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hj:diva-55965DOI: 10.1002/alz.12561ISI: 000753369600001PubMedID: 35142055Scopus ID: 2-s2.0-85124570907Local ID: HOA;intsam;798119OAI: oai:DiVA.org:hj-55965DiVA, id: diva2:1641568
Funder
Swedish Research Council, 2019-02226AlzheimerfondenKnut and Alice Wallenberg FoundationKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseGun och Bertil Stohnes StiftelseRegion StockholmStiftelsen Gamla TjänarinnorEU, European Research Council, 804371The Dementia Association - The National Association for the Rights of the Demented2022-03-022022-03-022023-03-28Bibliographically approved