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Occupational complexity and cognition in the FINGER multidomain intervention trial
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).ORCID iD: 0000-0002-8617-0355
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
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2022 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 18, no 12, p. 2438-2447Article in journal (Refereed) Published
Sustainable development
3. Good health and well-being
Abstract [en]

Introduction: Lifetime exposure to occupational complexity is linked to late-life cognition, and may affect benefits of preventive interventions.

Methods: In the 2-year multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated, through post hoc analyses (N = 1026), the association of occupational complexity with cognition. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles.

Results: Higher levels of occupational complexity were associated with better baseline cognition. Measures of occupational complexity had no association with intervention effects on cognition, except for occupational complexity with data, which was associated with the degree of intervention-related gains for executive function.

Discussion: In older adults at increased risk for dementia, higher occupational complexity is associated with better cognition. The cognitive benefit of the FINGER intervention did not vary significantly among participants with different levels of occupational complexity. These exploratory findings require further testing in larger studies.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 18, no 12, p. 2438-2447
Keywords [en]
Alzheimer's disease, cognitive decline, cognitive reserve, dementia, intelligence, multidomain intervention, occupational complexity, prevention, randomized controlled trials
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hj:diva-55965DOI: 10.1002/alz.12561ISI: 000753369600001PubMedID: 35142055Scopus ID: 2-s2.0-85124570907Local ID: HOA;intsam;798119OAI: oai:DiVA.org:hj-55965DiVA, id: diva2:1641568
Funder
Swedish Research Council, 2019-02226AlzheimerfondenKnut and Alice Wallenberg FoundationKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseGun och Bertil Stohnes StiftelseRegion StockholmStiftelsen Gamla TjänarinnorEU, European Research Council, 804371The Dementia Association - The National Association for the Rights of the DementedAvailable from: 2022-03-02 Created: 2022-03-02 Last updated: 2023-03-28Bibliographically approved

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Kåreholt, Ingemar

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