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A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
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2021 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 53, no 9, p. 1276-1282Article in journal (Refereed) Published
Abstract [en]

Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer’s disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer’s disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer’s disease to identify further genetic variants that contribute to Alzheimer’s pathology.

Place, publisher, year, edition, pages
Springer Nature, 2021. Vol. 53, no 9, p. 1276-1282
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Neurology
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URN: urn:nbn:se:hj:diva-54690DOI: 10.1038/s41588-021-00921-zISI: 000694666000007PubMedID: 34493870Scopus ID: 2-s2.0-85114746630Local ID: ;intsam;766606OAI: oai:DiVA.org:hj-54690DiVA, id: diva2:1595671
Funder
NIH (National Institute of Health)Wellcome trust, 082604/2/07/ZThe Research Council of Norway, 223273,248778,248980Available from: 2021-09-20 Created: 2021-09-20 Last updated: 2022-10-31Bibliographically approved

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Karlsson, Ida K.

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