This chapter uses a 2 by 2 adjustment model to study the changes in population and employment across 381 US metropolitan areas between 1990 and 2015. Population levels depend upon house prices (amenities) and location (climate), while employment levels depend upon wages and industrial specialization (manufacturing, professional services). Important distinctions are drawn between the 100 largest economies (Brookings group) and the 281 smaller ones. Supply-induced growth has dominated change in the larger areas, while demand-induced growth has prevailed in the smaller areas. Utility patents are shown to have had a positive impact on employment, where this impact has been greater in the nation’s large metropolitan economies. Estimates are made for four overlapping 10-year intervals and for data pooled across the 25 years.