Small and medium-sized enterprises (SMEs) that are manufacturers are challenged during the coronavirus pandemic since their customers have been locking down their production due to different reasons. This is a disruptive and unpredicted situation for manufacturing SMEs and at the same time a lot of possibilities for manufacturing other types of products is shown. This paper will discuss challenges for SMEs in such a disruptive situation, and reflect if it is possible to be prepared? And if so or not, what can we learn for future and reducing the risks if or when next pandemic situation occurs.