Background: Fatigue is one of the most debilitating symptoms of MS and can negatively affect daily life, restricting occupational performance and participation. Occupational therapy plays an important role in providing fatigue management interventions to support individual performance and participation. There has been limited evidence about fatigue management interventions relevant to occupational therapy for people with MS. Aims: This scoping review aims to identify and map different therapeutic fatigue management interventions for adults with MS and illustrate the influence on activity, occupational performance and participation. Material and Methods: Six databases and grey literature were searched. Interventions were coded according to the ‘International Classification of Functioning, Disability and Health’(ICF) and in succession linked to the constructs of the ‘Person, Environment, Occupation and Performance-Model’ (PEOP). Results: Fourteen papers published between 2009 and 2019 met inclusion criteria. Two articles explored participation. Group-based and self-management interventions were found. Interventions also matched relevant domains of the ICF and PEOP framework for occupational therapy practice. Conclusions and Significance: Furthermore, fatigue management interventions can positively affect occupational performance, participation and activity. Group-based interventions including theory as well as practical exercises, which also provided opportunities for social interaction, seemed to be optimal for reducing fatigue.