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Effect of acute transcranial magnetic stimulation on intracellular signalling in human skeletal muscle
Division of Neuropediatrics, Department of Women’s and Children’s Health, Karolinska Institutet and Astrid Lindgren’s Pediatric Hospital.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm.
Division of Neuropediatrics, Department of Women’s and Children’s Health, Karolinska Institutet and Astrid Lindgren’s Pediatric Hospital.
Jönköping University, School of Health and Welfare, HHJ, Dep. of Rehabilitation. Jönköping University, School of Health and Welfare, HHJ. CHILD.ORCID iD: 0000-0001-8994-8786
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2020 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVE: To investigate the potential of an acute bout of transcranial electrical stimulation to induce anabolic signalling.

DESIGN: Experimental intervention on healthy subjects.

SUBJECTS: Ten healthy subjects, 5 women and 5 men (mean age (standard deviation (SD) 32 years (SD 4)).

METHODS: The quadriceps muscle was stimulated at a frequency of 10 Hz for 10 s, followed by 20 s of rest, repeated 40 times over 20 min. Electromyography and force data were collected for all transcranial electrical stimulation sequences. Muscle biopsies were obtained from the vastus lateralis muscle before and 1 and 3 h after stimulation.

RESULTS: One bout of transcranial electrical stimulation decreased phosphorylation of AKT at Thr308 (1 h: -29%, 3 h: -38%; p < 0.05) and mTOR phosphorylation at Ser2448 (1 h: -10%; ns, 3 h: -21%; p < 0.05), both in the anabolic pathway. Phosphorylation of AMPK, ACC and ULK1 were not affected. c-MYC gene expression was unchanged following transcranial electrical stimulation, but rDNA transcription decreased (1 h: -28%, 3 h: -19%; p < 0.05). PGC1α-ex1b mRNA increased (1 h: 2.3-fold, 3 h: 2.6-fold; p < 0.05), which also correlated with vastus lateralis electromyography activity, while other PGC-1α variants were unchanged.

CONCLUSION: Acute transcranial electrical stimulation of skeletal muscle in weight-bearing healthy individuals did not induce anabolic signalling, and some signs of impaired muscle anabolism were detected, suggesting limited potential in preventing muscle wasting.

Place, publisher, year, edition, pages
Stiftelsen Rehabiliteringsinformation , 2020.
Keywords [en]
skeletal muscle, transcranial magnetic stimulation, electromyography
National Category
Orthopaedics
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URN: urn:nbn:se:hj:diva-47479DOI: 10.2340/16501977-2643PubMedID: 31938801OAI: oai:DiVA.org:hj-47479DiVA, id: diva2:1387453
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Futurum - Academy for Health and Care, Jönköping County Council, SwedenSwedish Society of MedicineAvailable from: 2020-01-21 Created: 2020-01-21 Last updated: 2020-01-21

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