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IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.
Department of Psychology, Indiana University Southeast, New Albany, IN, United States.
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2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, p. 1-8Article in journal (Refereed) Epub ahead of print
Abstract [en]

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

Place, publisher, year, edition, pages
Cambridge University Press, 2019. p. 1-8
Keywords [en]
Dementia, early life adversity, gene–environment interplay, health, socioeconomic status
National Category
Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics
Identifiers
URN: urn:nbn:se:hj:diva-46509DOI: 10.1017/thg.2019.76PubMedID: 31544729Scopus ID: 2-s2.0-85072661257Local ID: ;HHJARNISOAI: oai:DiVA.org:hj-46509DiVA, id: diva2:1359565
Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2019-10-09

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Dahl Aslan, Anna K.

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Public Health, Global Health, Social Medicine and EpidemiologyMedical Genetics

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