IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An UpdateShow others and affiliations
2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 22, no 6, p. 809-816Article in journal (Refereed) Published
Abstract [en]
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.
Place, publisher, year, edition, pages
Cambridge University Press, 2019. Vol. 22, no 6, p. 809-816
Keywords [en]
Dementia, early life adversity, gene–environment interplay, health, socioeconomic status
National Category
Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics and Genomics
Identifiers
URN: urn:nbn:se:hj:diva-46509DOI: 10.1017/thg.2019.76ISI: 000517442200061PubMedID: 31544729Scopus ID: 2-s2.0-85072661257Local ID: HOA HHJ 2019;HHJARNISOAI: oai:DiVA.org:hj-46509DiVA, id: diva2:1359565
2019-10-092019-10-092025-02-10Bibliographically approved