Responsible Research and Innovation (RRI) is currently gaining significant attention from policy and academic circles. The publication of the papers in wide variety of journals signifies the fact that discussion about RRI is raised in interdisciplinary field of studies. Furthermore, interest in RRI is growing in recognition of the role of RRI in making science and innovation for society with society. Yet relevant knowledge is widely dispersed across disciplines, which makes it not only ambiguous, but also, difficult on bringing RRI into research and innovation practices. In this study, we conducted a systematic literature review (SLR) of 126 conceptual papers on RRI from the period 2003-2016 and conducted thematic and ontological analysis of those 126 papers selected for the study. On so doing, we categorized the emerged themes into RRI domain ontology as drivers, tools, enablers, outcomes and barriers. The paper thus makes original contribution in understanding RRI and its aspirations and what could it mean for adopting RRI practices in research and innovation activities. The paper also suggests avenues for future research.