Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The CODATwins Project: The current status and recent findings of COllaborative Project of Development of Anthropometrical Measures in Twins
Show others and affiliations
2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 22, no 6, p. 800-808Article in journal (Refereed) Published
Abstract [en]

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status. 

Place, publisher, year, edition, pages
Cambridge University Press, 2019. Vol. 22, no 6, p. 800-808
Keywords [en]
birth size, BMI, education, height, heritability, international comparisons, Twins, adult, article, birth weight, body mass, controlled study, disease course, dizygotic twins, feasibility study, female, genetic susceptibility, genetic variation, human, infancy, major clinical study, male, sample size, smoking, social status
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:hj:diva-45600DOI: 10.1017/thg.2019.35ISI: 000517442200060PubMedID: 31364586Scopus ID: 2-s2.0-85070056867Local ID: ;HHJARNISOAI: oai:DiVA.org:hj-45600DiVA, id: diva2:1343701
Available from: 2019-08-19 Created: 2019-08-19 Last updated: 2020-03-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Dahl Aslan, Anna K.

Search in DiVA

By author/editor
Dahl Aslan, Anna K.
By organisation
HHJ, Institute of GerontologyHHJ. ARN-J (Aging Research Network - Jönköping)
In the same journal
Twin Research and Human Genetics
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 40 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf