As technology is rapidly changing, organizations nowadays are confronted with significant changes, as the latest digital revolution is causing enormous transformation worldwide. However, these changes caused by technologies come with difficult questions about the impact on jobs, skills, and the nature of work itself. As a consequence, companies are facing great revisions within job design in the digital era. The purpose of this study is to contribute to existing literature with regards to changing job characteristics and job design in a digitally transforming business landscape. The intention of our research therefore is to explore how the digital transformation and (disruptive) technologies change job design and job characteristics and subsequently impact employees’ job motivation, performance, and satisfaction. For this study a qualitative research approach within a multiple-case study was used. In total eight case companies were willing to participate and thereby contribute to this research. The empirical data was collected by means of semi-structured interviews and subsequently analyzed by means of a content analysis. The results of our study corroborate a significant impact of digital transformation on job characteristics and job design. We have found that all job characteristics are being influenced by the increase in digitalization and the constant introduction of disruptive technologies. Caused by these changes in job characteristics, there is a significant impact on motivation, performance, and satisfaction.